Severe Statin-induced Rhabdomyolysis Following Cholestatic Hepatitis Induced by Amoxicillin-clavulanate

  • Rachele Rapetti First Internal Medicine Division, "Maggiore della Carità" University Hospital, Novara, Italy
  • Elena Merlotti First Internal Medicine Division, "Maggiore della Carità" University Hospital, Novara, Italy
  • Mattia Bellan First Internal Medicine Division, "Maggiore della Carità" University Hospital, Novara, Italy
  • Gian Piero Schianca First Internal Medicine Division, "Maggiore della Carità" University Hospital, Novara, Italy
  • Mario Pirisi Department of Clinical and Experimental Medicine, First Internal Medicine Division, University of Eastern Piedmont "A.Avogadro", Novara, Italy

Abstract

We report the case of an 86-year-old man with a past history of coronary disease admitted to ourinternal medicine department for severe asthenia and weakness due to rhabdomyolysis. Three days earlier, he had been discharged from a gastroenterology unit with adiagnosis of amoxicillin–clavulanate-induced acute cholestatic hepatitis. A review of his drugs revealed that he had taken atorvastatin 10 mg daily in theprevious six years, without clinical or laboratory signs of myopathy. Atorvastatin was therefore stopped, with gradual improvement of therhabdomyolysis. All concomitant drug therapy needs to be reassessed in elderly patients, especially when they become acutely ill.

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  • Published: 2014-05-26

    Issue: Vol 1 (2014) (view)

    Section: Articles

    How to cite:
    Rapetti, R., Merlotti, E., Bellan, M., Schianca, G., & Pirisi, M. (2014). Severe Statin-induced Rhabdomyolysis Following Cholestatic Hepatitis Induced by Amoxicillin-clavulanate. European Journal of Case Reports in Internal Medicine, 1(1). https://doi.org/https://doi.org/10.12890/2014_000065