A Case of Hypocalcaemia Due to Vitamin D Deficiency in ‘Hikikomori’ Syndrome

  • Takahiro Miyakoshi Diabetes Center, Department of Neurology, Aizawa Hospital, Matsumoto
  • Mamoru Satoh Division of Clinical Mass Spectrometry, Chiba University Hospital, Chiba
  • Fumio Nomura Division of Clinical Mass Spectrometry, Chiba University Hospital, Chiba
  • Takao Hashimoto Department of Neurology, Aizawa Hospital, Matsumoto
  • Toru Aizawa Diabetes Center, Department of Neurology, Aizawa Hospital, Matsumoto

Keywords

Hikikomori syndrome, Hypocalcemia, Hypovitaminosis D

Abstract

Objective: To describe hypocalcaemia due to vitamin D deficiency in ‘hikikomori’ syndrome.

Materials and methods: A 37-year-old man with ‘hikikomori’ syndrome for a year was admitted with hypocalcaemia (serum ionic calcium 1.17 mmol/l). Serum 1,25(OH)2-vitamin D3 determined by liquid chromatography–tandem mass spectrometry was depressed at 12.1 pg/ml (29.0 pmol/l) and plasma intact PTH elevated at 324 ng/l. Administration of 1 ?g/day 1?(OH)-vitamin D3 and 1 g/day calcium lactate for 1 week normalized calcium and PTH, and raised 1,25(OH)2-vitamin D3 to low normal levels.

Conclusion: This is the first report of hypocalcaemia due to vitamin D deficiency in a patient with ‘hikikomori’ syndrome.

VIEW THE ENTIRE ARTICLE

References

  • Watts J. Public health experts concerned about 'hikikomori'. Lancet 2002;359:1131.
  • Kato TA, Tateno M, Shinfuku N, et al. Does the 'hikikomori' syndrome of social withdrawal exist outside Japan? A preliminary international investigation. Soc Psychiatry Psychiatr Epidemiol 2012;47:1061–1075.
  • Herrmann M, Farrell CL, Pusceddu I, Fabregat-Cabello N, Cavalier E. Assessment of vitamin D status - a changing landscape. Clin Chem Lab Med 2016;55:3–26.
  • Mochizuki A, Kodera Y, Saito T, et al. Preanalytical evaluation of serum 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 measurements using LC-MS/MS. Clin Chim Acta 2013;420:114–120.
  • Satoh M, Ishige T, Ogawa S, et al. Development and validation of the simultaneous measurement of four vitamin D metabolites in serum by LC-MS/MS for clinical laboratory applications. Anal Bioanal Chem 2016;408:7617–7627.
  • Published: 2017-09-28

    Issue: Vol. 4 No. 7 (view)

    Section: Articles

    How to cite:
    1.
    Miyakoshi T, Satoh M, Nomura F, Hashimoto T, Aizawa T. A Case of Hypocalcaemia Due to Vitamin D Deficiency in ‘Hikikomori’ Syndrome. EJCRIM 2017;4 doi:10.12890/2017_000634.

    Most read articles by the same author(s)