Still’s-like Disease Induced by Breast Implants in a Middle-Aged Female Health Professional

  • Giagkos Michael Lavranos Department of Internal Medicine, Nicosia University General Hospital, Nicosia
  • Demetra Kouma Department of Internal Medicine, Nicosia University General Hospital, Nicosia
  • Antonis Deveros Department of Internal Medicine, Nicosia University General Hospital, Nicosia
  • Georgia Pigiotou Department of Internal Medicine, Nicosia University General Hospital, Nicosia
  • Georgios Samanis Department of Internal Medicine, Nicosia University General Hospital, Nicosia
  • Chrysostomos Zintilis Department of Internal Medicine, Nicosia University General Hospital, Nicosia

Keywords

breast implants, fever of unknown origin, silicone, Still disease

Abstract

We report a case of silicone-induced Still’s-like inflammatory syndrome diagnosed after extensive investigation in the department of internal medicine of a secondary hospital. A 45-year-old female healthcare specialist presented with fever, headache, sore throat, myalgia and fatigue. A history of breast augmentation surgery in 2007 was confirmed. Physical examination of the patient was normal while laboratory tests showed a very high white blood cell count. The patient was admitted to hospital due to suspected infection and further laboratory tests were carried out. Inflammatory markers were persistently high despite empirical treatment with doxycycline for possible infection by Rickettsia/Coxiella. As the fever did not resolve and the patient had not improved after more than 3 weeks, the case was investigated as fever of unknown origin. Eventually, the existence of liver granulomas as well as the presence of anti-silicone antibodies confirmed the diagnosis of silicone-induced Still’s-like inflammatory syndrome. In conclusion, this case supports a linkage between silicone breast implants and autoimmune connective tissue diseases.

Author Biographies

Giagkos Michael Lavranos ,
Department of Internal Medicine, Nicosia University General Hospital, Nicosia Giagkos Lavranos MD, MA, PhD
Assistant Professor  of Public Health
Vice Chair, Department of Health Sciences
European University Cyprus

Demetra Kouma ,
Department of Internal Medicine, Nicosia University General Hospital, Nicosia Internist, Department of Medicine, Nicosia General Hospital

Antonis Deveros ,
Department of Internal Medicine, Nicosia University General Hospital, Nicosia Medical Student, Department of Medicine, Nicosia General Hospital

Georgia Pigiotou ,
Department of Internal Medicine, Nicosia University General Hospital, Nicosia Medical Student, Department of Medicine, Nicosia General Hospital

Georgios Samanis ,
Department of Internal Medicine, Nicosia University General Hospital, Nicosia Medical Student, Department of Medicine, Nicosia General Hospital

Chrysostomos Zintilis ,
Department of Internal Medicine, Nicosia University General Hospital, Nicosia Director, Department of Medicine, Nicosia General Hospital

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References

Vojdani A, Brautbar N, Campbell AW. Antibody to silicone and native macromolecules in women with silicone breast implants. Immunopharmacol Immunotoxicol 1994;16:497–523.

Yamaguchi M, Ohta A, Tsunematsu T, Kasukawa R, Mizushima Y, Kashiwagi H, et al. Preliminary criteria for classification of adult Still's disease. J Rheumatol 1992;19:424–430.

Oliver DW. Anti-silicone antibodies and silicone containing breast implants. Br J Plast Surg 2000;53:410–414.

Tugwell P, Wells G, Peterson J, Welch V, Page J, Davison C, et al. Do silicone breast implants cause rheumatologic disorders? A systematic review for a court-appointed national science panel. Arthritis Rheum 2001;44:2477–2484.

Jara LJ, Medina G, Gómez-Bañuelos E, Saavedra MA, Vera-Lastra O. Still's disease, lupus-like syndrome, and silicone breast implants. A case of 'ASIA' (Shoenfeld's syndrome). Lupus 2012;21:140–145.

Błasiak A, Błachowicz A, Gietka A, Rell-Bakalarska M, Franek E. Still's disease in patient with silicone breast implants: case report. Pol Arch Med Wewn 2008;118:65–67.

Katayama I, Umeda T, Nishioka K. Adult Still's-disease-like illness in a patient with silicone breast implants. Clin Rheumatol 1998;17:81-82.

Montano M, Vaatola M, Santoro L, La Regina M, Curigliano V, Manna R, et al. Systemic inflammatory diseases and silicone breast prostheses: report of a case of adult still disease and review of the literature. Am J Med Sci 2004;327:102–104.

Cretel E, Richard MA, Jean R, Durand JM. Still’s-like disease, breast prosthesis and collagen implants. Rheumatol Int 2001;20:129–131.

Published: 2017-01-27

Issue: Vol. 4 No. 1 (view)

Section: Articles

How to cite:
1.
Lavranos GM, Kouma D, Deveros A, Pigiotou G, Samanis G, Zintilis C. Still’s-like Disease Induced by Breast Implants in a Middle-Aged Female Health Professional. EJCRIM [Internet]. 2017Jan.27 [cited 2020Sep.26];4(1). Available from: https://ejcrim.com/index.php/EJCRIM/article/view/513