EXTRAMEDULLARY PARAVERTEBRAL MASS: AN UNUSUAL PRESENTATION OF HAIRY CELL LEUKAEMIA
  • Valentini Samanidou
    1st Division of Internal Medicine and Infectious Diseases’ Unit, University General Hospital of Ioannina, Ioannina, Greece
  • Aikaterini Panteli
    1st Division of Internal Medicine and Infectious Diseases’ Unit, University General Hospital of Ioannina, Ioannina, Greece
  • Liontos Angelos
    1st Division of Internal Medicine and Infectious Diseases’ Unit, University General Hospital of Ioannina, Ioannina, Greece
  • Biros Dimitrios
    1st Division of Internal Medicine and Infectious Diseases’ Unit, University General Hospital of Ioannina, Ioannina, Greece
  • Diamantina Lymperatou
    1st Division of Internal Medicine and Infectious Diseases’ Unit, University General Hospital of Ioannina, Ioannina, Greece
  • Haralampos Milionis
    1st Division of Internal Medicine and Infectious Diseases’ Unit, University General Hospital of Ioannina, Ioannina, Greece
  • Kapsali Eleni
    Department of Haematology, University General Hospital of Ioannina, Ioannina, Greece

Keywords

Hairy cell leukaemia, paravertebral mass, extramedullary

Abstract

Background: Hairy cell leukaemia (HCL) is an uncommon, indolent, B-cell, lymphoproliferative disorder typically involving peripheral blood, spleen and bone marrow. It is commonly presenting with pancytopenia, monocytopenia and massive splenomegaly, while accounting for 2% of lymphoid leukaemias. Cases of extranodal lesions caused by HCL are rare, although these have been reported. Here, we report a case of HCL presenting as a paravertebral mass without systemic involvement.
Case description: A 58-year-old man was admitted to our hospital due to progressive difficulty walking for a month, without any other symptoms. Blood examination noted mild anaemia with Hb=12.6 g/dl and mild thrombocytopenia of 140,000/ul. Magnetic resonance imaging (MRI) and computed tomography (CT) imaging demonstrated a T6 posterior paravertebral mass lesion, extending into the spinal canal with metastatic bone lesions along the thoracic and lumbar spine. Further imaging study with CT indicated mild splenomegaly (13.4 cm) and an enlarged abdominal lymph node (3.5 cm) near celiac trifurcation.
Conclusion: A core-needle biopsy from the paravertebral mass was performed. Results showed small-sized cells with round or oval nuclei, and pale cytoplasm with immunophenotype: B-cell origination with CD20+, Cyclin D1+, DBA.44+, Annexin+ and BRAF+, indicative of HCL.

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    Published: 2024-07-26
    Issue: 2024: LATEST ONLINE (view)

    How to cite:
    1.
    Samanidou V, Panteli A, Angelos L, Dimitrios B, Lymperatou D, Milionis H, Eleni K. EXTRAMEDULLARY PARAVERTEBRAL MASS: AN UNUSUAL PRESENTATION OF HAIRY CELL LEUKAEMIA. EJCRIM 2024;11 doi:10.12890/2024_004707.