Tumour-to-tumour metastasis: a rare case of prostate cancer metastasising to primary lung adenocarcinoma
  • Rachelle Hamadi
    Department of Hematology Oncology, SUNY Downstate Medical Center, New York, USA
  • Imad Karam
    Department of Hematology Oncology, SUNY Downstate Medical Center, New York, USA
  • Salman Khan
    Department of Internal Medicine, Staten Island University Hospital, New York, USA
  • Sylvester Homsy
    Department of Hematology Oncology, SUNY Downstate Medical Center, New York, USA
  • Carol Luhrs
    Department of Hematology Oncology, SUNY Downstate Medical Center, New York, USA

Keywords

Prostate cancer, lung adenocarcinoma, tumour-to-tumour metastasis

Abstract

Tumour-to-tumour metastasis (TTM) is a rare phenomenon that clinicians should be aware of when evaluating patients with a history of prostate cancer. We present the diagnosis and management of an 80-year-old former smoker with high-risk prostate cancer, who developed a lung nodule consistent with TTM. The patient had concurrent primary lung adenocarcinoma and metastatic prostate cancer, making this a unique case of dual primary and metastatic malignancies. The complexity of this case highlights the need for comprehensive evaluation and interdisciplinary management in patients with multiple malignancies. The literature review reveals that these are extremely rare occurrences, with most cases involving metastasis to the second primary tumour. Despite the challenges in diagnosing preoperatively, it is important to consider TTM as a possibility in patients with prostate cancer who present with a lung nodule. This report presents one of the few documented cases of TTM. It also reviews relevant cases in the literature and discusses the current situation in relation to established criteria for classifying combination tumours.

VIEW THE ENTIRE ARTICLE

References

  • Sakai S, Morinaga Y, Koshiba A, Mori T, Kusuki I, Kitawaki J. Unexpected tumor-to-tumor metastasis of synovial sarcoma within leiomyoma: a case report and literature review. J Obstet Gynaecol Res 2020;46:1216–1223.
  • Campbell LV Jr, Gilbert E, Chamberlain CR Jr, Watne AL. Metastases of cancer to cancer. Cancer 1968;22:635–643.
  • Manini C, Provenza C, Andrés L, Imaz I, Guarch R, Nunziata R, et al. Tumor-to-tumor metastases involving clear cell renal cell carcinomas: a diagnostic challenge for pathologists needing clinical correlation. Clin Pract 2023;13:288–296.
  • Miller V, Hoellwarth JS, Hankins ML, McGough R, Schoedel K. Tumor-to-tumor metastasis: prostate carcinoma metastatic to soft tissue sarcoma, a previously unreported event. Int J Surg Pathol 2020;28:196–199.
  • Kabukcuoglu F, Kabukcuoglu Y, Tanik C, Sakiz D, Karsidag S. Breast carcinoma metastasis in recurrent myxoid liposarcoma. Pathol Oncol Res 2009;15:467–471.
  • Tanjak P, Suktitipat B, Vorasan N, Juengwiwattanakitti P, Thiengtrong B, Songjang C, et al. Risks and cancer associations of metachronous and synchronous multiple primary cancers: a 25-year retrospective study. BMC Cancer 2021;21:1045.
  • Fabozzi SJ, Schellhammer PF, el-Mahdi AM. Pulmonary metastases from prostate cancer. Cancer 1995;75:2706–2709.
  • Tohfe M, Baki SA, Saliba W, Ghandour F, Ashou R, Ghazal G, et al. Metastatic prostate adenocarcinoma presenting with pulmonary symptoms: a case report and review of the literature. Cases J 2008;1:316.
  • Anton RC, Schwartz MR, Kessler ML, Cagle PT. Metastatic carcinoma of the prostate mimicking primary carcinoid tumor of the lung and mediastinum. Pathol Res Pract 1998;194:753–758.
  • Fukushima Y, Ota T, Mukasa A, Uozaki H, Kawai K, Saito, N. Tumor-to-tumor metastasis: lung adenocarcinoma metastasizing to vestibular schwannoma suspected on preoperative [18F]-fluorodeoxyglucose positron emission tomography imaging. World Neurosurg 2012;78:553.e9–553.e13.
  • Wu PS, Pan CC. Lung adenocarcinoma metastasizing into a renal angiomyolipoma. Int J Surg Pathol 2015;23:230–233.
  • Fidler IJ. The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited. Nat Rev Cancer 2003;3:453–458.

    • Views: 0
    HTML downloads: 0
    PDF downloads: 0

    Published: 2024-07-01
    Issue: 2024: LATEST ONLINE (view)

    How to cite:
    1.
    Hamadi R, Karam I, Khan S, Homsy S, Carol Luhrs. Tumour-to-tumour metastasis: a rare case of prostate cancer metastasising to primary lung adenocarcinoma. EJCRIM 2024;11 doi:10.12890/2024_004579.

    Most read articles by the same author(s)