Autoimmune myelofibrosis revealing a systemic lupus erythematosus
  • Fatimaezzahra Bensalek
    Department of Internal Medicine, University Hospital Centre Mohammed VI, Marrakech, Morocco
  • Hajar Joulal
    Department of Internal Medicine, University Hospital Centre Mohammed VI, Marrakech, Morocco
  • Jaouad Yousfi
    Department of Internal Medicine, University Hospital Centre Mohammed VI, Marrakech, Morocco
  • Mouna Zahlane
    Department of Internal Medicine, University Hospital Centre Mohammed VI, Marrakech, Morocco
  • Leila Benjilali
    Department of Internal Medicine, University Hospital Centre Mohammed VI, Marrakech, Morocco
  • Lamiaa Essaadouni
    Department of Internal Medicine, University Hospital Centre Mohammed VI, Marrakech, Morocco

Keywords

Autoimmune myelofibrosis, systemic lupus erythematosus, corticosteroid therapy

Abstract

Background: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, characterised by multi-organ affections. Haematological involvement is a common manifestation of SLE, consisting of autoimmune peripheral cytopenia. Autoimmune myelofibrosis (AIMF) is a rare cause of cytopenia in SLE; it could precede or be concurrent with the diagnosis of SLE. There are few studies that describe this association.
Case description: We report a case of AIMF revealing the diagnosis of SLE in a 34-year-old female, presented with episodes of gingival bleeding associated with peripheral inflammatory polyarthralgia, photosensitivity and deterioration of general condition. Clinical examination revealed a soft pitting oedema in the lower limbs. Laboratory investigations showed a pancytopenia, inflammatory biological syndrome, with positive 24-hour proteinuria and anti-native DNA antibodies. A bone marrow biopsy showed diffuse myelofibrosis associated with maturation disorders and no tumour infiltrate. Renal biopsy revealed proliferative glomerulonephritis class III with immune deposits.
Conclusion: The association of AIMF with SLE has been rarely reported, and it could be another cause for cytopenia in SLE.

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    Published: 2024-05-13
    Issue: 2024: Vol 11 No 6 (view)

    How to cite:
    1.
    Bensalek F, Joulal H, Yousfi J, Zahlane M, Benjilali L, Essaadouni L. Autoimmune myelofibrosis revealing a systemic lupus erythematosus. EJCRIM 2024;11 doi:10.12890/2024_004511.