False-negative PET/CT scan with metastatic sebaceous carcinoma: an important diagnostic consideration
  • Tong Ren
    Department of Internal Medicine, USF Morsani College of Medicine/HCA Healthcare Oak Hill Hospital, Brooksville, USA
  • Jennifer Foster
    Department of Internal Medicine, USF Morsani College of Medicine/HCA Healthcare Oak Hill Hospital, Brooksville, USA
  • Alex Wu
    Department of Internal Medicine, USF Morsani College of Medicine/HCA Healthcare Oak Hill Hospital, Brooksville, USA
  • Alisher Hamidullah
    Department of Internal Medicine, USF Morsani College of Medicine/HCA Healthcare Oak Hill Hospital, Brooksville, USA
  • Eric Sladek
    Department of Internal Medicine, USF Morsani College of Medicine/HCA Healthcare Oak Hill Hospital, Brooksville, USA

Keywords

False-negative PET/CT, sebaceous carcinoma, rare cancer, diagnostic limitations

Abstract

Positron emission tomography (PET) has gained widespread acceptance as a valuable diagnostic tool for cancer. It is rare for a PET/CT scan to overlook the presence of metastatic disease. Sebaceous carcinoma is an uncommon malignant tumour that typically originates in the skin of the eyelid. In this case report, we present a unique case involving a metastatic sebaceous carcinoma that was not initially detected by a PET/CT scan in an 88-year-old female. Therefore, clinicians must maintain a heightened awareness of sebaceous carcinoma and exercise caution when making decisions solely based on PET scan results. It is crucial to recognise this potential limitation of PET scans in sebaceous carcinoma and consider further diagnostic approaches to ensure timely and accurate detection of sebaceous carcinoma.

VIEW THE ENTIRE ARTICLE

References

  • Kyllo RL, Brady LK, Hurst EA. Sebaceous carcinoma: review of the literature. Dermatol Surg 2015;41:1–15.
  • Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, et al. Sebaceous carcinoma: evidence-based clinical practice guidelines. Lancet Oncol 2019;20:e699–e714.
  • Tripathi R, Chen Z, Li L, Bordeaux JS. Incidence and survival of sebaceous carcinoma in the United States. J Am Acad Dermatol 2016;75:1210–1215.
  • Kumabe A, Kawase T, Miura K, Tada Y, Masubuchi T, Kamata SE, et al. Sebaceous carcinoma of the parotid gland: F-18 FDG PET/CT findings. Clin Nucl Med 2010;35:260–262.
  • Ferreira I, Wiedemeyer K, Demetter P, Adams DJ, Arends MJ, Brenn T. Update on the pathology, genetics and somatic landscape of sebaceous tumours. Histopathology 2020;75:640–649.
  • Muqit MM, Foot B, Walters SJ, Mudhar HS, Roberts F, Rennie IG. Observational prospective cohort study of patients with newly-diagnosed ocular sebaceous carcinoma. Br J Ophthalmol 2013;97:47–51.
  • Desiato VM, Byun YJ, Nguyen SA, Thiers BH, Day TA. Sebaceous carcinoma of the eyelid: a systematic review and meta-analysis. Dermatol Surg 2021;47:104–110.

    • Views: 152
    HTML downloads: 21
    PDF downloads: 83

    Published: 2024-05-14
    Issue: 2024: Vol 11 No 6 (view)

    How to cite:
    1.
    Ren T, Foster J, Wu A, Hamidullah A, Sladek E. False-negative PET/CT scan with metastatic sebaceous carcinoma: an important diagnostic consideration. EJCRIM 2024;11 doi:10.12890/2024_004491.