Severe gastrointestinal cytomegalovirus infection in a patient diagnosed with late onset combined immunodeficiency
  • Georgina Sauqué Pintos
    Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain
  • Arnau Antolí Gil
    Department of Internal Medicine, Bellvitge University Hospital
  • Gemma Rocamora Blanch
    Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain; Adult Primary Immunodeficiency Unit, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain
  • Renzo Avila Espinoza
    Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain; Adult Primary Immunodeficiency Unit, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain
  • Rosario Taco Sánchez
    Department of Anatomical Pathology, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain
  • Núria Sabé Fernández
    Adult Primary Immunodeficiency Unit, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain
  • Xavier Solanich Moreno
    Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain; Adult Primary Immunodeficiency Unit, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain

Keywords

Primary Immunodeficiency, late onset combined immunodeficiency, opportunistic infection, cytomegalovirus

Abstract

Late onset combined immunodeficiency (LOCID) is a rare variant of common variable immunodeficiency (CVID), typically affecting adult patients who present with opportunistic infections (OI) and/or low CD4+ T lymphocytes. Diagnostic delay is common due to the rareness of this entity, increasing morbidity and mortality. We report on a 66-year-old male who developed a severe gastrointestinal cytomegalovirus (CMV) infection, refractory to antiviral treatment and anti-cytomegalovirus specific human immunoglobulin administration, with a fatal outcome due to an undiagnosed LOCID.

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    Published: 2024-05-13
    Issue: 2024: Vol 11 No 6 (view)

    How to cite:
    1.
    Sauqué Pintos G, Antolí Gil A, Rocamora Blanch G, Avila Espinoza R, Taco Sánchez R, Sabé Fernández N, Solanich Moreno X. Severe gastrointestinal cytomegalovirus infection in a patient diagnosed with late onset combined immunodeficiency. EJCRIM 2024;11 doi:10.12890/2024_004390.