Left Ventricle Non-Compaction Myocardium and Thrombophilia in a Pregnant Woman

  • Elena A. Kochmareva Pirogov Russian National Research Medical University, Moscow, Russian Federation, 117997
  • Valentin A. Kokorin Pirogov Russian National Research Medical University, Moscow, Russian Federation, 117997
  • Evgenia A. Kondrashova City Clinical Hospital No. 15 named after O.M. Filatov, Moscow, Russian Federation
  • Nadejda V. Khokhlova City Clinical Hospital No. 15 named after O.M. Filatov, Moscow, Russian Federation
  • Argishti G. Vardanyan Pirogov Russian National Research Medical University, Moscow, Russian Federation, 117997
  • Ilya A. Kokorin Pirogov Russian National Research Medical University, Moscow, Russian Federation, 117997
  • Dmitry A. Doroshenko City Clinical Hospital No. 15 named after O.M. Filatov, Moscow, Russian Federation

Keywords

non-compaction myocardium, pregnancy, heart failure, thrombophilia

Abstract

Non-compaction of the ventricular myocardium (NCM) is a genetic cardiomyopathy usually due to mutationof the G4.5 gene located in the Xq28 chromosomal region. This congenital disorder is characterized by pronounced trabeculations and intertrabecular recesses resulting from abnormal embryogenesis between the fifth and eighth fetal weeks. The reported prevalence in the general population is between 0.014% and 1.3%. The classic triad of complications includes heart failure, ventricular arrhythmias and systemic embolic events, although some patients have an asymptomatic form. NCM is commonly diagnosed by echocardiography, but contrast ventriculography, CT and MRI can also be used. Here we present a case of left ventricle NCM, manifested after respiratory infection, in a pregnant patient with congenital thrombophilia and a history of myocardial infarction.

Author Biographies

Elena A. Kochmareva ,
Pirogov Russian National Research Medical University, Moscow, Russian Federation, 117997 Hospital Therapy №1 Department

Valentin A. Kokorin ,
Pirogov Russian National Research Medical University, Moscow, Russian Federation, 117997 Hospital therapy #1 department

Argishti G. Vardanyan ,
Pirogov Russian National Research Medical University, Moscow, Russian Federation, 117997 Hospital therapy #1 department

Ilya A. Kokorin ,
Pirogov Russian National Research Medical University, Moscow, Russian Federation, 117997 Hospital therapy #1 department

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References

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  • Published: 2016-07-27

    Issue: Vol. 3 No. 5 (view)

    Section: Articles

    How to cite:
    1.
    Kochmareva EA, Kokorin VA, Kondrashova EA, Khokhlova NV, Vardanyan AG, Kokorin IA, Doroshenko DA. Left Ventricle Non-Compaction Myocardium and Thrombophilia in a Pregnant Woman. EJCRIM 2016;3 doi:10.12890/2016_000432.