Gastrointestinal complications of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome managed by parenteral nutrition
  • Simona Horná
    Clinic of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, and University Hospital in Martin, Martin, Slovakia
  • Martin Jozef Péč
    Clinic of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, and University Hospital in Martin, Martin, Slovakia
  • Juraj Krivuš
    Clinic of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, and University Hospital in Martin, Martin, Slovakia
  • Renáta Michalová
    Clinic of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, and University Hospital in Martin, Martin, Slovakia
  • Štefan Sivák
    Clinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, and University Hospital in Martin, Martin, Slovakia
  • Peter Galajda
    Clinic of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, and University Hospital in Martin, Martin, Slovakia
  • Marián Mokáň
    Clinic of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, and University Hospital in Martin, Martin, Slovakia

Keywords

MELAS, nutrition, superior mesenteric artery syndrome

Abstract

MELAS – an acronym for mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes – is a multiorgan disease caused by a mutation in mitochondrial DNA (mtDNA). Its clinical manifestations are highly variable; mainly stroke-like episodes, seizures, recurrent headaches, or muscle weakness. However, gastrointestinal complications such as chronic intestinal pseudo-obstruction (IPO), pancreatitis, gastroparesis and hepatopathy are also common. In this report we describe a young patient with gastrointestinal complication of MELAS which led to superior mesenteric artery syndrome (SMAS). It is rare but not surprising combination and should be considered in cases with significant weight loss and resistance to symptomatic treatment. The optimal energy support is the main pillar of the treatment.

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    Published: 2024-01-22
    Issue: 2024: Vol 11 No 2 (view)


    How to cite:
    1.
    Horná S, Péč MJ, Krivuš J, Michalová R, Sivák Štefan, Galajda P, Mokáň M. Gastrointestinal complications of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome managed by parenteral nutrition. EJCRIM 2024;11 doi:10.12890/2024_004268.