Might IgA be a Biomarker of Disease Activity in Takayasu Arteritis?
  • Lorenzo Vantaggio
    Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
  • Chiara Pellicano
    Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
  • Marzia Miglionico
    Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
  • Giuseppina Cusano
    Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
  • Marcella Visentini
    Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

Keywords

Vasculitis, Takayasu arteritis, IgA, biomarkers, Infliximab

Abstract

Takayasu arteritis is a systemic vasculitis of the large vessels and mainly affects Japanese and Southeast Asian women in the second and third decades of life. Inflammatory infiltrate affects the full thickness of the vessel wall, inducing progressive lumen stenosis and occlusion. The main biomarkers of disease activity are the ESR, CRP and serum levels of circulating cytokines.

This case report describes the clinical history of a young woman with Takayasu disease with high serum levels of IgA at onset. IgA remained elevated with persistence of disease activity, and normalized only when the patient was treated with an anti-TNF agent (infliximab), which also induced a clinical response in the vasculitis. 

IgA levels, together with other inflammatory parameters, may be considered a biomarker of disease activity. 

 

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    Published: 2022-12-02
    Issue: 2022: Vol 9 No 12 (view)

    How to cite:
    1.
    Vantaggio L, Chiara Pellicano, Marzia Miglionico, Giuseppina Cusano, Marcella Visentini. Might IgA be a Biomarker of Disease Activity in Takayasu Arteritis?. EJCRIM 2022;9 doi:10.12890/2022_003664.