Might IgA be a Biomarker of Disease Activity in Takayasu Arteritis?
  • Lorenzo Vantaggio
    Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
  • Chiara Pellicano
    Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
  • Marzia Miglionico
    Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
  • Giuseppina Cusano
    Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
  • Marcella Visentini
    Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

Keywords

Vasculitis, Takayasu arteritis, IgA, biomarkers, Infliximab

Abstract

Takayasu arteritis is a systemic vasculitis of the large vessels and mainly affects Japanese and Southeast Asian women in the second and third decades of life. Inflammatory infiltrate affects the full thickness of the vessel wall, inducing progressive lumen stenosis and occlusion. The main biomarkers of disease activity are the ESR, CRP and serum levels of circulating cytokines.

This case report describes the clinical history of a young woman with Takayasu disease with high serum levels of IgA at onset. IgA remained elevated with persistence of disease activity, and normalized only when the patient was treated with an anti-TNF agent (infliximab), which also induced a clinical response in the vasculitis. 

IgA levels, together with other inflammatory parameters, may be considered a biomarker of disease activity. 

 

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References

  • Keser G, Aksu K, Direskeneli H. Takayasu arteritis: an update. Turk J Med Sci 2018 Aug 16;48(4):681–697. doi: 10.3906/sag-1804-136
  • Zaldivar Villon MLF, de la Rocha JAL, Espinoza LR. Takayasu arteritis: recent developments. Curr Rheumatol Rep 2019 Jul 18;21(9):45. doi: 10.1007/s11926-019-0848-3
  • Águeda AF, Monti S, Luqmani RA, Buttgereit F, Cid M, Dasgupta B, et al. Management of Takayasu arteritis: a systematic literature review informing the 2018 update of the EULAR recommendation for the management of large vessel vasculitis. RMD Open 2019 Sep 23;5(2):e001020. doi: 10.1136/rmdopen-2019-001020
  • Samson M, Espígol-Frigolé G, Terrades-García N, Prieto-González S, Corbera-Bellalta M, Alba-Rovira R. Biological treatments in giant cell arteritis & Takayasu arteritis. Eur J Intern Med 2018 Apr;50:12–19. doi: 10.1016/j.ejim.2017.11.003
  • Leong KW, Ding JL. The unexplored roles of human serum IgA. DNA Cell Biol 2014 Dec;33(12):823–829. doi: 10.1089/dna.2014.2639
  • Woof JM, Kerr MA. The function of immunoglobulin A in immunity. J Pathol 2006 Jan;208(2):270–282. doi: 10.1002/path.1877
  • de Sousa-Pereira P, Woof JM. IgA: structure, function, and developability. Antibodies (Basel) 2019 Dec 5;8(4):57. doi: 10.3390/antib8040057
  • Yazdani R, Azizi G, Abolhassani H, Aghamohammadi A. Selective IgA deficiency: epidemiology, pathogenesis, clinical phenotype, diagnosis, prognosis and management. Scand J Immunol 2017 Jan;85(1):3–12. doi: 10.1111/sji.12499
  • Leong KW, Ding JL. The unexplored roles of human serum IgA. DNA Cell Biol 2014 Dec;33(12):823–829. doi: 10.1089/dna.2014.2639
  • Cavatorta F, Campisi S, Trabassi E, Zollo A, Salvidio G. IgA nephropathy associated with Takayasu's arteritis: report of a case and review of the literature. Am J Nephrol 1995;15(2):165–167. doi: 10.1159/000168824
  • Ito N, Shirai T, Toyohara T, Hashimoto H, Sato H, Fujii H, et al. Coexistence of IgA nephropathy and renal artery stenosis in Takayasu arteritis: case report and literature review. Rheumatol Int 2022 Jan 11. doi: 10.1007/s00296-021-05066-0. Online ahead of print.
  • Wang H, Zhang C, Tong Z, Bu X. Elevated serum levels of immunoglobulin A correlate with the possibility of readmission in patients with microscopic polyangiitis. J Thorac Dis 2017 May;9(5):1201–1208. doi: 10.21037/jtd.2017.03.166
  • Wei Y, Zhao C, Liang J, Jin Z, Hua B, Wang H, et al. Factors associated with event-free survival in Chinese patients with Takayasu's arteritis. Clin Rheumatol 2021 May;40(5):1941–1948. doi: 10.1007/s10067-020-05481-x
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    Published: 2022-12-02
    Issue: 2022: Vol 9 No 12 (view)


    How to cite:
    1.
    Vantaggio L, Chiara Pellicano, Marzia Miglionico, Giuseppina Cusano, Marcella Visentini. Might IgA be a Biomarker of Disease Activity in Takayasu Arteritis?. EJCRIM 2022;9 doi:10.12890/2022_003664.