Pantoprazole-related Symptomatic Hyponatremia

Filipa Ferreira; Sofia Mateus; Ana Rita Santos; Hugo Moreira; Nuno Ribeiro Ferreira

doi:10.12890/2015_000341

Pantoprazole-related Symptomatic Hyponatremia

Filipa Ferreira Oncology Department, Hospital São Francisco Xavier - Centro Hospitalar Lisboa Ocidental
Sofia Mateus Internal Medicine Department, Hospital São Francisco Xavier - Centro Hospitalar Lisboa Ocidental
Ana Rita Santos Internal Medicine Department, Hospital São Francisco Xavier - Centro Hospitalar Lisboa Ocidental
Hugo Moreira Internal Medicine Department, Hospital São Francisco Xavier - Centro Hospitalar Lisboa Ocidental
Nuno Ribeiro Ferreira Internal Medicine Department, Hospital São Francisco Xavier - Centro Hospitalar Lisboa Ocidental

DOI: https://doi.org/10.12890/2015_000341

Keywords

Hyponatremia, Pantoprazole, Proton pump inhibitors, Syndrome of Inappropriate Antidiuretic Hormone Secretion

Abstract

Hyponatremia is the most common electrolyte balance disorder, especially in the elderly and polymedicated population. The authors report the case of an 83-year-old man with symptomatic severe hyponatremia due to Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) related to pantoprazole. Pantoprazole was discontinued and serum sodium levels reached normal values in two months. To the authors’ knowledge, this is the second reported case of pantoprazole-related hyponatremia and, while most patients with hyponatremia related to proton pump inhibitors have mild symptoms, this patient had severe manifestations.

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