Secondary Haemophagocytic Lymphohistiocytosis Syndrome (HLH) After Intravesical Instillation of Bacillus Calmette-Guérin (BCG): A Case Report and Review of the Literature

  • Konstantinos Manganas First Department of Propaedeutic Internal Medicine, Laiko General Hospital, Athens, Greece
  • Angelara Maria First Department of Propaedeutic Internal Medicine, Laiko General Hospital, Athens, Greece
  • Ioanna Bountzona First Department of Propaedeutic Internal Medicine, Laiko General Hospital, Athens, Greece
  • George Karamanakos First Department of Propaedeutic Internal Medicine, Laiko General Hospital, Athens, Greece
  • Angelos Toskas First Department of Propaedeutic Internal Medicine, Laiko General Hospital, Athens, Greece

Keywords

BCGitis, HLH syndrome, intravesical BCG instillation

Abstract

Intravesical bacillus Calmette-Guérin (BCG) instillation is widely used for the treatment of superficial bladder cancer. BCGitis is a serious immune-mediated complication with systematic manifestations and a high mortality rate. Here, we describe a case of a 64-year-old male patient who presented with haemophagocytic lymphohistiocytosis syndrome (HLH) after BCG instillation and was effectively treated with high-dose dexamethasone, intravenous immunoglobulins and anti-tuberculosis treatment.

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  • Published: 2022-10-21

    Issue: 2022: Vol 9 No 10 (view)

    Section: Articles

    How to cite:
    1.
    Manganas K, Maria A, Bountzona I, Karamanakos G, Toskas A. Secondary Haemophagocytic Lymphohistiocytosis Syndrome (HLH) After Intravesical Instillation of Bacillus Calmette-Guérin (BCG): A Case Report and Review of the Literature. EJCRIM 2022;9 doi:10.12890/2022_003395.