Cholesterol Granuloma: An Underrecognized Cause of Benign Lung Granuloma

  • Sara Seife Hassen Internal Medicine Department, Hamad Medical Corporation, Doha, Qatar
  • Gawahir A Ali Department of Infectious Diseases, Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar
  • Ashraf Ahmed Internal Medicine Department, Hamad Medical Corporation, Doha, Qatar
  • Wael Goravey Department of Infectious Diseases, Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar
DOI: https://doi.org/10.12890/2022_003264

Keywords

Pulmonary tuberculosis, invasive aspergillosis, type II diabetes, immunocompromised

Abstract

A cholesterol granuloma is a benign lesion that can occur in various organs, mimicking other pathologies. We present the case of a 35-year-old man presenting with asymptomatic lung and pleural lesions which were suspected to be pulmonary tuberculosis but found to be cholesterol granuloma on biopsy. Cholesterol granulomas are a rare mimic of common lung pathology and should be considered in the differential diagnosis if the initial investigations are not informative.

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References

  • Fisher M, Roggli V, Merten D, Mulvihill D, Spock A. Coexisting endogenous lipoid pneumonia, cholesterol granulomas, and pulmonary alveolar proteinosis in a pediatric population: a clinical, radiographic, and pathologic correlation. Pediatr Pathol 1992 Jan 1;12(3):365–383.
  • Murugasu E, Yong TT, Yoon CP. Invasive middle ear cholesterol granuloma involving the basal turn of the cochlea with profound sensorineural hearing loss. Otol Neurotol 2004 May;25(3):231–235.
  • Rinaldo A, Ferlito A, Cureoglu S, Devaney KO, Schachern PA, Paparella MM. Cholesterol granuloma of the temporal bone: a pathologic designation or a clinical diagnosis? Acta Otolaryngol 2005 Jan;125(1):86–90.
  • Kay JM, Heath D, Hasleton PS, Littler WA. Aetiology of pulmonary cholesterol-ester granulomas. Br J Dis Chest 1970 Jan 1;64(1):55–57.
  • Sato K, Takahashi H, Amano H, Uekusa T, Dambara T, Kira S. Diffuse progressive pulmonary interstitial and intra-alveolar cholesterol granulomas in childhood. Eur Resp J 1996 Nov 1;9(11):2419–2422.
  • Nolan RL, McAdams HP, Sporn TA, Roggli VL, Tapson VF, Goodman PC. Pulmonary cholesterol granulomas in patients with pulmonary artery hypertension: chest radiographic and CT findings. Am J Roentgenol 1999 May;172(5):1317–1319.
  • Manola M, Casorelli I, Pietrafesa FL, Mottola, Lacerenza D, Battiloro G, et al. Cholesterol granuloma of the frontal sinus: a case report. Case Rep Otolaryngol 2012;2012:515986.
  • Gaillard F. Cholesterol granuloma. Reference article, Radiopaedia.org. Available from: https://radiopaedia.org/articles/cholesterol-granuloma (accessed 16 Feb 2022).
  • Connor SEJ, Leung R, Natas S. Imaging of the petrous apex: a pictorial review. Br J Radiol 2008 May;81(965):427–435.
  • Loverdos K, Fotiadis A, Kontogianni C, Iliopoulou M, Gaga M. Lung nodules: a comprehensive review on current approach and management. Ann Thorac Med 2019 Oct-Dec;14(4):226–238
  • Thorne MC, Gebarski SS, Telian SA. Rapid expansion in a previously indolent cholesterol cyst: a need for lifelong follow-up. Otol Neurotol 2006 Jan;27(1):124–126.

    • Published: 2022-03-29

    Issue: 2022: Vol 9 No 3 (view)

    Section: Articles

    How to cite:
    1.
    Hassen S, Ali G, Ahmed A, Goravey W. Cholesterol Granuloma: An Underrecognized Cause of Benign Lung Granuloma. EJCRIM 2022;9 doi:10.12890/2022_003264.