McKittrick-Wheelock Syndrome: A Neoplastic Cause of Electrolyte Imbalance
  • Inês de Sousa Miranda
    Internal Medicine Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal
  • Joana Ferreira
    General Surgery Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal
  • Sara Rocha
    Internal Medicine Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal
  • Marta Monteiro
    Internal Medicine Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal
  • José Guilherme
    General Surgery Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal
  • Raquel Domingos
    Internal Medicine Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal

Keywords

McKittrick-Wheelock syndrome, electrolyte imbalance, tubulovillous adenoma

Abstract

The authors present the case of a 79-year-old woman who presented with chronic secretory diarrhoea and severe electrolyte imbalance. A large rectal tubulovillous adenoma was discovered, leading to surgical resection of the tumour with complete resolution of the diarrhoea and electrolyte imbalance. The diagnosis of McKittrick-Wheelock syndrome was made.

We hope this case report will contribute to a greater awareness among health professionals about this clinical condition. A multidisciplinary approach is essential for the best outcome.

VIEW THE ENTIRE ARTICLE

References

  • McKittrick LS, Wheelock FC. Carcinoma of the colon. Springfield, IL: Charles C Thomas; 1954, p. 61.
  • Ochard MR, Hooper J, Wright JA, McCarthy K. A systematic review of McKittrick-Wheelock syndrome. Ann R Coll Surg Engl 2018;100:591–597.
  • Malik S, Mallick B, Mattar K, Kumar V, Sharma V, Rana SS. Malignant McKittrick–Wheelock syndrome as a cause of acute kidney injury and hypokalemia: report of a case and review of literature. Intractable Rare Dis Res 2016;5:218–221.
  • Winstanley V, Little M, Wadsworth C, Cohen P, Martin NM. The McKittrick-Wheelock syndrome: a case of acute renal failure due to neoplastic cholera. Ren Fail 2008;30:469–473.
  • Steven K, Lange P, Bukhave P, Rask-Madsen J. Prostaglandin E2-mediated secretory diarrhea in villous adenoma of rectum: effect of treatment with indomethacin. Case Rep Gastroenterol 1981;80(6):1562–1566.
  • Mathew DK, Schmidt K, Sangha G. Indomethacin therapy effective in a patient with depletion syndrome from secretory villous adenoma. BMJ Case Rep 2017;2017:bcr2016217211.
  • Sumrien H, Dadnam C, Hewitt J, McCarthy K. Feasibility of transanal minimally invasive surgery (TAMIS) for rectal tumours and its impact on quality of life – the Bristol series. Anticancer Res 2016;36(4):2005–2009.
  • Targarona EM, Hernandez PM, Balague C, Martinez C, Hernández J, Pulido D, et al. McKittrick–Wheelock syndrome treated by laparoscopy: report of 3 cases. Surg Laparosc Endosc Percutan Tech 2008;18(5):536–538.
  • Choi WH, Ryuk J, Kim HJ, Park SY, Park JS, Kim JG, et al. A case of giant rectal villous tumor with severe fluid–electrolyte imbalance treated by laparoscopic low anterior resection. J Korean Surg Soc 2012;82(5):325–329.

    • Views: 430
    HTML downloads: 82
    PDF downloads: 211

    Published: 2022-03-24
    Issue: 2022: Vol 9 No 3 (view)

    How to cite:
    1.
    de Sousa Miranda I, Ferreira J, Rocha S, Monteiro M, Guilherme J, Domingos R. McKittrick-Wheelock Syndrome: A Neoplastic Cause of Electrolyte Imbalance. EJCRIM 2022;9 doi:10.12890/2022_003227.

    Similar Articles

    You may also start an advanced similarity search for this article.