Unintentional Dual Benefit: Improvement in Secondary Polycythemia in a Patient Receiving Chemotherapy for Metastatic Clear Cell Renal Cell Carcinoma
  • Brooke Kania
    St. Joseph’s University Medical Center, Paterson, NJ, USA
  • Erinie Mekheal
    St. Joseph’s University Medical Center, Paterson, NJ, USA
  • Sherif Roman
    St. Joseph’s University Medical Center, Paterson, NJ, USA
  • Nader Mekheal
    St. Joseph’s University Medical Center, Paterson, NJ, USA
  • Vinod Kumar
    St. Joseph’s University Medical Center, Paterson, NJ, USA
  • Michael Maroules
    St. Joseph’s University Medical Center, Paterson, NJ, USA

Keywords

Metastatic renal cell carcinoma, everolimus, paraneoplastic syndrome, secondary polycythemia, EPO-producing tumour

Abstract

Complete blood counts are frequently collected from cancer patients, but laboratory findings may be misleading. Secondary polycythemia can occur in renal cell carcinoma (RCC) due to erythropoietin (EPO) stimulation. Therefore, complete blood counts should be closely monitored to prevent complications such as thrombosis. We discuss the case of a 47-year-old man with metastatic RCC who presented with secondary polycythemia that improved with chemotherapy. His secondary erythrocytosis was anticipated, but his haemoglobin levels were lower than expected after therapy. This article discusses the treatment and diagnosis of secondary polycythemia in patients with RCC.

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References

  • Ljungberg B, Rasmuson T, Grankvist K. Erythropoietin in renal cell carcinoma: evaluation of its usefulness as a tumor marker. Eur Urol 1992;21:160–3.
  • Michael A, Politi E, Havranek E, Corbishley C, Karapanagiotou L, Anderson C, et al. Prognostic significance of erythropoietin expression in human renal cell carcinoma. BJU Int 2007;100(2):291–4.
  • Palapattu GS, Kristo B, Rajfer J. Paraneoplastic syndromes in urologic malignancy: the many faces of renal cell carcinoma. Rev Urol 2002;4(4):163.
  • Murphy GP, Kenny GM, Mirand EA. Erythropoietin levels in patients with renal tumors or cysts. Cancer 1970;26(1):191–4.
  • Janik JE, Sharfman WH, Smith JW, Longo DL, Sznol M, Urba WJ, et al. Erythropoietin production. A potential marker for interleukin-2/interferon-responsive tumors. Cancer 1993;72(9):2656–9.
  • Michael A, Politi E, Havranek E, Corbishley C, Karapanagiotou L, Anderson C. Prognostic significance of erythropoietin expression in human renal cell carcinoma. BJU Int 2007;100(2):291–4.
  • Bunn HF, Gu J, Huang LE, Park JW, Zhu H. Erythropoietin: a model system for studying oxygen-dependent gene regulation. J Exp Biol 1998;201(8):1197–1201.
  • Messinezy M, Westwood NB, El-Hemaidi I, Marsden JT, Sherwood RS, Pearson TC. Serum erythropoietin values in erythrocytoses and in primary thrombocythaemia. Br J Haematol 2002;117(1):47–53.
  • Berlin NI. Diagnosis and classification of the polycythemias. Semin Hematol 1975 Oct;12(4):339–51.
  • Tefferi A, Rumi E, Finazzi G, Gisslinger H, Vannucchi AM, Rodeghiero F, et al. Survival and prognosis among 1545 patients with contemporary polycythemia vera: an international study. Leukemia 2013;27(9):1874–81.
  • Donati MB, Falanga A. Pathogenetic mechanisms of thrombosis in malignancy. Acta Haematol 2001;106(1–2):18–24.
  • Tanios GE, Doley PB, Munker R. Autoimmune hemolytic anemia associated with the use of immune checkpoint inhibitors for cancer: 68 cases from the Food and Drug Administration database and review. Eur J Haematol 2019;102(2):157–62.
  • Shameem R, Hamid MS, Wu S. Risk of anemia attributable to everolimus in patients with cancer: a meta-analysis of randomized controlled trials. Anticancer Res 2015;35(4):2333–40.
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    Published: 2022-02-18
    Issue: 2022: Vol 9 No 2 (view)


    How to cite:
    1.
    Kania B, Mekheal E, Roman S, Mekheal N, Kumar V, Maroules M. Unintentional Dual Benefit: Improvement in Secondary Polycythemia in a Patient Receiving Chemotherapy for Metastatic Clear Cell Renal Cell Carcinoma. EJCRIM 2022;9 doi:10.12890/2022_003125.

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