Nannizziopsis Immune Reconstitution Inflammatory Syndrome in a Patient with HIV: First Reported Case


HIV, immune reconstitution inflammatory syndrome, IRIS, Nannizziopsis


We describe the case of a 35-year-old HIV-positive male of African origin diagnosed with neurotoxoplasmosis and a Nannizziopsis spp. cavitating pulmonary lesion unmasking immune reconstitution inflammatory syndrome (IRIS).

The patient presented with headache, left hemiparesis and confusion. MRI of the brain showed two space-occupying lesions in the right basal ganglia and left parietal lobe typical for neurotoxoplasmosis. The patient tested positive for HIV and had advanced CD4 lymphopenia. After commencement of antiretroviral treatment, a CT scan of the chest showed a cavitating lesion in the right upper lobe. The diagnosis of Nannizziopsis spp. fungal infection was confirmed by DNA sequencing on a bronchial wash sample. The patient achieved complete recovery with antiretroviral therapy, standard neurotoxoplasmosis treatment and antifungal treatment with voriconazole for 12 weeks.



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  • Published: 2021-11-23

    Issue: 2021: Vol 8 No 11 (view)

    Section: Articles

    How to cite:
    Zhao Y, Nozdrin M, Dalla Pria A, Bracchi M. Nannizziopsis Immune Reconstitution Inflammatory Syndrome in a Patient with HIV: First Reported Case. EJCRIM 2021;8 doi:10.12890/2021_003021.