Platypnoea-Orthodeoxia Syndrome in COVID-19
  • Francesca Salvotti
    Third Medicine Division, Department of Medicine, ASST Spedali Civili di Brescia, Brescia, Italy; Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
  • Francesco Poiatti
    Third Medicine Division, Department of Medicine, ASST Spedali Civili di Brescia, Brescia, Italy; Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
  • Stefano Bressa
    Third Medicine Division, Department of Medicine, ASST Spedali Civili di Brescia, Brescia, Italy; Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
  • Giovanni Montani
    Third Medicine Division, Department of Medicine, ASST Spedali Civili di Brescia, Brescia, Italy
  • Matteo Nardin
    Third Medicine Division, Department of Medicine, ASST Spedali Civili di Brescia, Brescia, Italy
  • Damiano Rizzoni
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy; Division of Medicine, A.S.S.T. Spedali Civili di Brescia, Montichiari, Italy

Keywords

Platypnoea-orthodeoxia syndrome, COVID-19, SARS-CoV-2

Abstract

Platypnoea-orthodeoxia syndrome (POS) is a rare disorder and its pathophysiology has puzzled clinicians for years. Few cases of POS are described in COVID-19 patients in the literature, with a high variability of conditions related to the syndrome. 
In this article, we report the case of a patient admitted to our hospital for SARS-CoV-2 interstitial pneumonia, who developed POS during the hospitalization.

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References

  • Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review. JAMA 2020;324:782–793.
  • Harapan H, Itoh N, Yufika A, Winardi W, Keam S, Te H, et al. Coronavirus disease 2019 (COVID-19): a literature review. J Infect Public Health 2020;13:667–673.
  • Cheng TO. Platypnea-orthodeoxia syndrome: etiology, differential diagnosis, and management. Catheter Cardiovasc Interv 1999;47(1):64–66.
  • Longo C, Ruffini L, Zanoni N, Longo F, Accogli R, Graziani T, et al. Platypnea-orthodeoxia after fibrotic evolution of SARS-CoV-2 interstitial pneumonia. A case report. Acta Biomed 2020;91(3):1–7.
  • Agrawal A, Palkar A, Talwar A. The multiple dimensions of platypnea-orthodeoxia syndrome: a review. Respir Med 2017;129:31–38.
  • Gadre A, Highland KB, Mehta A. Reversible platypnea-orthodeoxia syndrome from ventilation-perfusion mismatch in interstitial lung disease: a novel etiology. Ann Am Thorac Soc 2016;13:137–138.
  • Tan GP, Ho S, Fan BE, Chotirmall SH, Tan CH, Lew SJW, et al. Reversible platypnea-orthodeoxia in COVID-19 acute respiratory distress syndrome survivors. Respir Physiol Neurobiol 2020;282:103515.
  • Singh K, Kadnur H, Ray A, Khanna P, Singh A, Wig N, et al. Platypnea-orthodeoxia in a patient with severe COVID-19 pneumonia. Monaldi Arch Chest Dis 2020;90(4):718–720.
  • Tham S, Ong P, Lee A, Tay M. Rehabilitation of patients with platypnea-orthodeoxia syndrome in COVID-19 pneumonia: two case reports. J Rehabil Med Clin Commun 2020;3(1):1000044.
  • Oldani S, Ravaglia C, Bensai S, Bertolovic L, Ghirotti C, Puglisi S, et al. Pathophysiology of light phenotype SARS-CoV-2 interstitial pneumonia: from histopathological features to clinical presentations. Pulmonology. Epub 2021 Mar 26. doi: 10.1016/j.pulmoe.2021.03.003.
  • Aayilliath AK, Singh K, Ray A, Wig N. Platypnoea-orthodeoxia syndrome in COVID-19. BMJ Case Rep 2021;14(5):2–5.
  • Ismail MA, Trevest K. Platypnoea-orthodeoxia syndrome in an older patient with COVID-19 pneumonia and orthostatic hypotension—a case of prolonged hospital admission. Age Ageing Epub 2021 Jul 16. doi: 10.1093/ageing/afab166.
  • Darif D, Hammi I, Kihel A, El Idrissi Saik I, Guessous F, Akarid K. The pro-inflammatory cytokines in COVID-19 pathogenesis: what goes wrong?Microb Pathog 2021;153:104799.
  • Munshi L, Del Sorbo L, Adhikari NKJ, Hodgson CL, Wunsch H, Meade MO, et al. Prone position for acute respiratory distress syndrome: a systematic review and meta-analysis. Ann Am Thorac Soc 2017;14:S280–S288.

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    Published: 2021-10-22
    Issue: 2021: Vol 8 No 10 (view)

    How to cite:
    1.
    Salvotti F, Poiatti F, Bressa S, Montani G, Nardin M, Rizzoni D. Platypnoea-Orthodeoxia Syndrome in COVID-19. EJCRIM 2021;8 doi:10.12890/2021_002849.

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