Recurrence of Graves’ Disease (a Th1-type Cytokine Disease) Following SARS-CoV-2 mRNA Vaccine Administration: A Simple Coincidence?

  • Guillaume Pierman Department of Endocrinology, Centre Hospitalier Universitaire de Mont-Godinne, Yvoir, Belgium
  • Etienne Delgrange Department of Endocrinology, Centre Hospitalier Universitaire de Mont-Godinne, Yvoir, Belgium
  • Corinne Jonas Department of Endocrinology, Centre Hospitalier Universitaire de Mont-Godinne, Yvoir, Belgium

Keywords

Hyperthyroidism, Graves' disease, vaccine, SARS-CoV-2

Abstract

Graves’ disease is the most frequent cause of hyperthyroidism in young women. This auto-immune disease is due to the production of class 1 IgG stimulating the TSH receptor. These antibodies are produced secondary to a Th1 immune response in which interferon gamma plays a key role. Vaccination is ongoing worldwide against SARS-CoV-2 and some of the vaccines include mRNA which seems to stimulate the Th1 immune response. Here, we report a case of recurrence of hyperthyroidism due to Graves’ disease following mRNA vaccination and discuss the possible implicated mechanism. This observation argues for a systematic study of a population of patients with previous Graves’ disease in order to assess the risk of recurrence following vaccination.

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  • Published: 2021-10-08

    Issue: 2021: Vol 8 No 9 (view)

    Section: Articles

    How to cite:
    1.
    Pierman G, Delgrange E, Jonas C. Recurrence of Graves’ Disease (a Th1-type Cytokine Disease) Following SARS-CoV-2 mRNA Vaccine Administration: A Simple Coincidence?. EJCRIM 2021;8 doi:10.12890/2021_002807.