The Development of Ecchymosis after Administration of Convalescent Serum in a Patient with COVID-19 Associated with Thrombocytosis

  • Rajashree Khot Department of General Medicine, AIIMS, Nagpur, Maharashtra, India
  • Sunita Kumbhalkar Department of General Medicine, AIIMS, Nagpur, Maharashtra, India
  • Richa Juneja Department of Pathology (Haematology), AIIMS, Nagpur, Maharashtra, India
  • Prashant P Joshi Department of General Medicine, AIIMS, Nagpur, Maharashtra, India
DOI: https://doi.org/10.12890/2021_002782

Keywords

COVID-19, thrombocytosis, convalescent plasma reaction, ecchymoses

Abstract

COVID-19 can have an unpredictable and severe course, leading to many hypotheses regarding its pathophysiology and clinical manifestations. Haematological manifestations are a significant predictor of disease severity. The most common observation is lymphopenia with an increased neutrophil:lymphocyte ratio. Platelets have been implicated in thrombogenic events, but the most frequently reported abnormality is mild thrombocytopenia.<br />
Here we present an interesting case of a patient with moderate COVID-19 who presented with cutaneous ecchymoses and thrombocytosis, and discuss this paradox.

Author Biographies

Sunita Kumbhalkar ,
Department of General Medicine, AIIMS, Nagpur, Maharashtra, India

Professor

Dept of General Medicine

All India Institute of Medical Sciences

Nagpur

Richa Juneja ,
Department of Pathology (Haematology), AIIMS, Nagpur, Maharashtra, India

Assistant Professor (Haematology)

Dept of Pathology

All India Institute of Medical Sciences

Nagpur

Prashant P Joshi ,
Department of General Medicine, AIIMS, Nagpur, Maharashtra, India

Professor

Dept of General Medicine

All India Institute of Medical Sciences

Nagpur

VIEW THE ENTIRE ARTICLE

References

  • Comer SP, Cullivan S, Szklanna PB, Weiss L, Cullen S, Kelliher S, et al. COVID-19 induces a hyperactive phenotype in circulating platelets. PLoS Biol 2021;19(2):e3001109. doi: 10.1371/journal.pbio.3001109.
  • Nagoba B, Gavkare A, Jamadar N, Mumbre S, Selkar S. Positive aspects, negative aspects and limitations of plasma therapy with special reference to COVID-19. J Infect Public Health 2020;13:1818–1822.
  • Al-Samkari H, Karp Leaf RS, Dzik WH, Carlson JCT, Fogerty AE, Waheed A, et al. COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection. Blood x2020;136(4):489–500. doi: 10.1182/blood.2020006520.
  • Jiang SQ, Huang QF, Xie WM, Lv C, Quan XQ. The association between severe COVID-19 and low platelet count: evidence from 31 observational studies involving 7613 participants. Br J Haematol 2020;190(1):e29–33.

    • Published: 2021-10-08

    Issue: 2021: Vol 8 No 9 (view)

    Section: Articles

    How to cite:
    1.
    Khot R, Kumbhalkar S, Juneja R, Joshi PP. The Development of Ecchymosis after Administration of Convalescent Serum in a Patient with COVID-19 Associated with Thrombocytosis. EJCRIM 2021;8 doi:10.12890/2021_002782.