A Rare Presentation of Cryptococcal Meningitis in a Treatment-Native Patient with Sarcoidosis

  • Mehak Qureshi McLaren Health Care, Flint/Michigan State University, Flint, Michigan, USA
  • Basel Abdelazeem McLaren Health Care, Flint/Michigan State University, Flint, Michigan, USA
  • Ashiya Khan McLaren Health Care, Flint/Michigan State University, Flint, Michigan, USA
  • Mazen Najjar McLaren Health Care, Flint/Michigan State University, Flint, Michigan, USA

Keywords

Cryptococcus neoformans, meningitis, sarcoidosis

Abstract

Cryptococcus neoformans is an encapsulated, yeast-like fungus that commonly lives in the environment due to soil contamination by the faeces of birds, especially pigeons. Cryptococcus is an opportunistic fungal infection frequently diagnosed in immunocompromised patients with HIV, steroid use, malignancy, history of organ transplantation, or, rarely, sarcoidosis. There have been only a few reports of cryptococcus infection in sarcoidosis patients who were not on steroid treatment. Here, we highlight the importance of considering opportunistic fungal infection in asymptomatic treatment-naive sarcoidosis patients. We present a patient with a history of asymptomatic, treatment-naive sarcoidosis who presented with headache and was diagnosed with cryptococcal meningitis in the presence of an idiopathic T-cell lymphopenia.

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References

  • van der Stoep JH, Sigstad E, Bredberg A. Sarcoidosis with cryptococcal infection apparently engaging only immune-privileged body compartments: a case report. BMC Infect Dis 2020;20(1):440.
  • Wagemakers A, Ang CW, Hagen F, Bot JCJ, Bomers MK, Visser MC, et al. Case report: chronic relapsing cryptococcal meningitis in a patient with low mannose-binding lectin and a low naive CD4 cell count. BMC Infect Dis 2019;19(1):846.
  • Leonhard SE, Fritz D, van de Beek D, Brouwer MC. Cryptococcal meningitis complicating sarcoidosis. Medicine (Baltimore) 2016;95(35):e4587.
  • Jain D, Najjar M, Azher Q, Bachuwa G. Cryptococcal sternal osteomyelitis in a healthy woman: a review of Cryptococcus neoformans. BMJ Case Rep 2013;2013:bcr2013009129.
  • Khattab A, Patruni S, Sealey ML. Rare presentation of cryptococcal meningitis in an immunocompetent patient. BMJ Case Rep 2019;12(5):e230003.
  • Published: 2021-08-09

    Issue: 2021: Vol 8 No 8 (view)

    Section: Articles

    How to cite:
    1.
    Qureshi M, Abdelazeem B, Khan A, Najjar M. A Rare Presentation of Cryptococcal Meningitis in a Treatment-Native Patient with Sarcoidosis. EJCRIM 2021;8 doi:10.12890/2020_002755.