Intoxication by Hand-Sanitizers and other Toxic Alcohols in a Low-Resource Setting: Two Case Reports
  • Micah Heldeweg
    Department of Intensive Care, Amsterdam University Medical Centers, location VUmc, Amsterdam, the Netherlands https://orcid.org/0000-0001-7420-8486
  • Louisa Kluijver
    Department of Internal Medicine, Alrijne Hospital, Leiden, the Netherlands
  • Kenrick Berend
    Department of Internal Medicine, Curaçao Medical Center, Curaçao

Keywords

Toxic alcohols, anion gap, osmolal gap, doctor delay

Abstract

Toxic alcohol poisoning can be lethal if not identified early and treated appropriately. Toxic alcohol assays are often unavailable in low-resource setting, so clinicians have to infer a diagnosis based on suspicion, repeated evaluation and biochemical course. We report a case of toxic alcohol poisoning concealed by auto-intoxication with in-hospital hand sanitizer. The eventual appearance of a concurrent high anion gap prompted dialysis. In another case, a comatose patient presented with a high osmolal gap and a high anion gap. Incorrect a priori opinions caused us to defer dialysis and the patient died shortly afterwards. Clinicians should be aware that toxic alcohol poisoning can produce a confusing diagnostic picture with an insidious course, and that doctor delay can prove fatal.

VIEW THE ENTIRE ARTICLE

References

  • Boba A. Management of acute alcoholic intoxication. Am J Emerg Med 1999;17:431.
  • Barceloux DG, Bond GR, Krenzelok EP, Cooper H, Vale JA. American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. Clin Toxicol 2002;40:415–446.
  • Brick J. Standardization of alcohol calculations in research. Alcohol Clin Exp Res 2006;30:1276–1287.
  • Jones AW. Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework. Forensic Sci Int 2010;200:1–20.
  • Berend K, Duits AJ. The role of the clinical laboratory in diagnosing acid–base disorders. Crit Rev Clin Lab Sci 2019;56:147–169.
  • Halperin ML, Hammeke M, Josse RG, Jungas RL. Metabolic acidosis in the alcoholic: a pathophysiologic approach. Metabolism 1983;32:308–315.
  • Kraut JA, Mullins ME. Toxic alcohols. N Eng J Med 2018;378:270–280.
  • Yost DA. Acute care for alcohol intoxication. Postgrad Med 2009;112(6):14–26.
  • Chu J, Wang RY, Hill NS. Update in clinical toxicology. Am J Respir Crit Care Med 2002;166:9–15.
  • Jammalamadaka D, Raissi S. Ethylene glycol, methanol and isopropyl alcohol intoxication. Am J Med Sci 2010;339:276–281.
  • Kraut JA, Kurtz I. Toxic alcohol ingestions: clinical features, diagnosis, and management. Am Soc Nephrol 2008;3:208–225.
  • Kostic MA, Dart RC. Rethinking the toxic methanol level. Clin Toxicol 2003;41:793–800.
  • Views: 529
    HTML downloads: 64
    PDF downloads: 261


    Published: 2021-08-03
    Issue: 2021: Vol 8 No 8 (view)


    How to cite:
    1.
    Heldeweg M, Kluijver L, Berend K. Intoxication by Hand-Sanitizers and other Toxic Alcohols in a Low-Resource Setting: Two Case Reports. EJCRIM 2021;8 doi:10.12890/2021_002751.