Systemic Lupus Erythematosus with Crohn’s Disease: A Rare Combination and Unusual Presentation

  • Abdulrahman Algassim Department of Medicine, King Saud Medical City, Riyadh, Saudi Arabia; Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
  • Naif Alghonaim Department of Rheumatology, King Saud Medical City, Riyadh, Saudi Arabia
  • Ibrahim Alruzug Department of Gastroenterology, King Saud Medical City, Riyadh, Saudi Arabia
  • Mohamed S Elbayoumy Department of Gastroenterology, King Saud Medical City, Riyadh, Saudi Arabia
  • Azza Atallah Department of Pathology, King Saud Medical City, Riyadh, Saudi Arabia
DOI: https://doi.org/10.12890/2021_002678

Keywords

Systemic lupus erythematosus, infliximab, Crohn's disease

Abstract

The coexistence of systemic lupus erythematosus (SLE) and Crohn’s disease (CD) is very rare. The usual sequence of occurrence is CD followed by SLE, where CD treatment with anti-tumour necrosis factor (anti-TNF) induces the latter. Here, we present a case of this rare combination but with sequence reversal. The patient was unresponsive to steroids and we achieved remission with infliximab.

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References

  • Jin X, Wang G, Xu X, Bai Y, An R, Jiang D. Coexistence of Crohn’s disease and systemic lupus erythematosus: a case report and literature review. Eur J Gastroenterol Hepatol 2020;32(9):1256–1262.
  • Calmet FH, Yarur AJ, Pukazhendhi G, Ahmad J, Bhamidimarri KR. Endoscopic and histological features of mycophenolate mofetil colitis in patients after solid organ transplantation. Ann Gastroenterol 2015;28(3):366–373.
  • João-Magalhães M, Lago P, Pedroto I. Crohn's disease and systemic lupus erythematosus: a rare and challenging association. Rev Esp Enferm Dig 2015;107(6):394–395.
  • Principi M, Di Leo A, Ingrosso M, Pisani A, Marangi S, Amoruso A, et al. Lupus nephritis improvement after anti-tumor necrosis factor alpha monoclonal antibody (infliximab) treatment for Crohn's disease: a case report. Immunopharmacol Immunotoxicol 2004;26(2):243–248.
  • Kagaya Y, Sakamoto H, Yano T, Sunada K, Lefor AK, Niki T, et al. Mucosal healing of Crohn's disease in a patient with concurrent systemic lupus erythematosus using infliximab. Clin J Gastroenterol 2017;10(3):244–249.
  • Toulemonde P, Alric L, Vallée F, Selves J, Duffaut M. [Association of disseminated lupus erythematosus and Crohn's disease]. Rev Med Interne 2001;22(4):385–388.
  • Katsanos KH, Voulgari PV, Goussia A, Oikonomou P, Christodoulou DK, Drosos AA, et al. Coexistence of Crohn's disease in a patient with systemic lupus erythematosus. Rheumatol Int 2013;33(8):2145–2148.
  • Virtanen AT, Haikarainen T, Raivola J, Silvennoinen O. Selective JAKinibs: prospects in inflammatory and autoimmune diseases. BioDrugs 2019;33(1):15–32.

    • Published: 2021-06-29

    Issue: 2021: Vol 8 No 6 (view)

    Section: Articles

    How to cite:
    1.
    Algassim A, Alghonaim N, Alruzug I, Elbayoumy MS, Atallah A. Systemic Lupus Erythematosus with Crohn’s Disease: A Rare Combination and Unusual Presentation. EJCRIM 2021;8 doi:10.12890/2021_002678.