Chronic Onset Form of Anti-HMG-CoA Reductase Myopathy
  • Noel Lorenzo Villalba
    Service de Médecine Interne, Diabète et Maladies Métaboliques, Hôpitaux Universitaires de Strasboug, France
  • Emmanuel Andrés
    Service de Médecine Interne, Diabète et Maladies Métaboliques, Hôpitaux Universitaires de Strasboug, France
  • Alain Meyer
    Service de Rhumatologie, Hôpitaux Universitaires de Strasbourg, France

Abstract

We report a case of anti-HMGCR myopathy mimicking limb-girdle muscular dystrophy in a 27-year-old male patient with no history of statin intake and presenting with a chronic onset form over 3 years. Treatment with prednisone and methotrexate was initiated with an insufficient response, so intravenous immunoglobulin was added. One year after initial treatment was started, as levels of creatine kinase (CK) were >1000 U/l, treatment with rituximab was added. Despite a 3-year delay before treatment, muscle strength improved even though CK levels remain elevated.

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    Published: 2021-06-08
    Issue: 2021: Vol 8 No 6 (view)

    How to cite:
    1.
    Lorenzo Villalba N, Andrés E, Meyer A. Chronic Onset Form of Anti-HMG-CoA Reductase Myopathy. EJCRIM 2021;8 doi:10.12890/2021_002672.

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