Delayed-onset Necrotizing Myositis following COVID-19 Infection
  • Sravani Lokineni
    Department of Internal Medicine, Rochester Regional Health, Rochester, NY, USA
  • Mahta Mortezavi
    Department of Allergy, Immunology and Rheumatology, Rochester Regional Health, Rochester, NY, USA


COVID-19, SARS-CoV-2, necrotizing autoimmune myositis


As the numbers of cases of COVID-19 continue to rise, the heterogeneity of its clinical manifestation continues to increase. Here, we describe a case of delayed-onset, biopsy-proven necrotizing myositis following infection with SARS-CoV-2.



  • Manzano GS, Woods JK, Amato AA. Covid-19-associated myopathy caused by type I interferonopathy. N Engl J Med 2020;383:2389–2390.
  • Dalakas MC. Inflammatory muscle diseases. N Engl J Med 2015;372(18):1734–1747.
  • Adler BL, Christopher-Stine L. Triggers of inflammatory myopathy: insights into pathogenesis. Discov Med 2018;25(136):75–83.
  • Paliwal VK, Garg RK, Gupta A, Tejan N. Neuromuscular presentations in patients with COVID-19. Neurol Sci 2020;41(11):3039–3056.
  • Zhang H, Charmchi Z, Seidman RJ, Anziska Y, Velayudhan V, Perk J. COVID-19-associated myositis with severe proximal and bulbar weakness. Muscle Nerve 2020;62(3):E57–E60.
  • Beydon M, Chevalier K, Al Tabaa O, Hamroun S, Delettre AS, Thomas M, et al. Myositis as a manifestation of SARS-CoV-2. Ann Rheum Dis 2020 Apr 23:annrheumdis-2020-217573. doi: 10.1136/annrheumdis-2020-217573. Online ahead of print.
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    Published: 2021-04-20
    Issue: 2021: Vol 8 No 4 (view)

    How to cite:
    Lokineni S, Mortezavi M. Delayed-onset Necrotizing Myositis following COVID-19 Infection. EJCRIM 2021;8 doi:10.12890/2021_002461.