Delayed Recognition of Levetiracetam-induced Pancytopenia

  • Mohammad Ammad Ud Din Internal Medicine, Rochester General Hospital, Rochester, New York, USA https://orcid.org/0000-0001-9083-636X
  • Syed Ather Hussain Internal Medicine, Rochester General Hospital, Rochester, New York, USA
  • Amy Bodrog Hematology/Oncology, Rochester General Hospital, Rochester, New York, USA

Keywords

Drug-induced-pancytopenia, thrombocytopenia, levetiracetam, hematology, anti-epileptics

Abstract

Blood dyscrasias associated with levetiracetam use can be difficult to identify, especially when other potential differential diagnoses are concurrently present. Here we present a 57-year-old man with metastatic adenocarcinoma of unknown primary origin on levetiracetam who initially presented with an in-stent thrombosis of the right external iliac vein and then developed worsening thrombocytopenia followed by pancytopenia. Levetiracetam was not identified as the culprit until other causes like platelet consumption, heparin-induced thrombocytopenia, idiopathic immune thrombocytopenic purpura, and bone marrow involvement by metastatic disease were ruled out.

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  • Published: 2021-03-30

    Issue: Vol 8 No 3 (view)

    Section: Articles

    How to cite:
    1.
    Ammad Ud Din M, Ather Hussain S, Bodrog A. Delayed Recognition of Levetiracetam-induced Pancytopenia. EJCRIM 2021;8 doi:10.12890/2021_002449.