Granulomatosis with Polyangiitis: Recurrence or Treatment Consequences?
  • Andreia Diegues
    Internal Medicine Department, Unidade Local de Saúde do Nordeste, Portugal
  • Joana Tavares
    Nephrology Department, Centro Hospitalar Universitário do Porto, Portugal
  • Diogo Sá
    athological Anatomy Department, Centro Hospitalar Universitário do Porto, Portugal
  • João Oliveira
    Nephrology Department, Centro Hospitalar Universitário do Porto, Portugal
  • Diana Fernandes
    Internal Medicine Department, Unidade Local de Saúde do Nordeste, Portugal
  • Josefina Santos
    Nephrology Department, Centro Hospitalar Universitário do Porto, Portugal
  • Guillerme Rocha
    Nephrology Department, Centro Hospitalar Universitário do Porto, Portugal

Keywords

ANCA-PR3-associated vasculitis, granulomatosis with polyangiitis, intracranial hypertension, lung nodules

Abstract

Granulomatosis with polyangiitis (GPA) is the most common antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We describe the case of a 38-year-old woman with relapsing GPA who presented with intracranial hypertension, followed by the appearance of cavitated lung nodules despite treatment with azathioprine. Clinical improvement and ANCA titre reduction were observed after rituximab treatment. We report a rare form of GPA relapse and highlight the challenge of following-up patients with GPA, in whom can be hard to distinguish relapse from the consequences of long-term immunosuppression.

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    Published: 2021-04-22
    Issue: 2021: Vol 8 No 4 (view)

    How to cite:
    1.
    Diegues A, Tavares J, Sá D, Oliveira J, Fernandes D, Santos J, Rocha G. Granulomatosis with Polyangiitis: Recurrence or Treatment Consequences?. EJCRIM 2021;8 doi:10.12890/2021_002448.

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