Hepcidin and Ferritin Levels in Fever of Unknown Origin: Is There a New Biomarker?

  • Ana Lopez Aparicio Servicio Medicina Interna, Hospital General Universitario Gregorio Marañon, Madrid, Spain.
  • Alejandro García-Espona-Pancorbo Servicio Medicina Interna, Hospital General Universitario Gregorio Marañon, Madrid, Spain.
  • Marta Clavero-Olmos Servicio Medicina Interna, Hospital General Universitario Gregorio Marañon, Madrid, Spain.
  • Inmaculada Muñoz-Roldán Servicio Medicina Interna, Hospital General Universitario Gregorio Marañon, Madrid, Spain.
  • Alejandro del Castillo-Rueda Unidad de Ferropatología y Radicalosis, Servicio de Medicina Interna, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Keywords

Still disease, hyperferritinemia, hepcidin

Abstract

Background and objectives: Significantly elevated serum ferritin levels are associated with both iron overload and some inflammatory conditions. Hepcidin is a protein that interferes with iron absorption in inflammatory states and acts as an acute-phase reactant.

Materials and methods: Here we report the case a 33-year-old patient who presented with high fever, skin lesions and arthralgia lasting for 2 weeks. His ferritin level was 13,800 µg/l and his hepcidin level was 61 ng/dl.

Results: The final diagnosis was adult onset Still's disease. The condition evolved satisfactorily with steroid treatment, but after several weeks the patient presented with an unexpected recurrence.

Conclusions: Hepcidin is a good inflammatory marker that could be useful in the differential diagnosis of hyperferritinaemia.

Author Biographies

Ana Lopez Aparicio,
Servicio Medicina Interna, Hospital General Universitario Gregorio Marañon, Madrid, Spain.

Internal Medicine Department

References

  • Kadavath S, Efthimion P. Adult-onset Still’s disease-pathogenesis, clinical manifestations and new treatment options. Ann Med 2015;47:6–14.

  • Moore C, Ormseth M, Fuchs H. Causes and significance of markedly elevated serum ferritin levels in an academic medical centre. J Clin Rheum 2013;19:324–248.

  • Del Castillo-Rueda A, Mastkiv N, Moreno- Carralero MI, Morán-Jiménez MJ. Serum hepcidin levels in hospitalized patients. A pilot study. Am J Hematol 2013;88:E226.

  • Pietrangelo A. Hepcidin in human iron disorders: therapeutic implications. J Hepatol 2011;54:173–181.

  • Mecklenburg I, Reznik D, Fasler-Kan E, Drewe J, Belglinger C, Hruz P. Serum hepcidin concentrations correlate with ferritin in patients with inflammatory bowel disease. J Crohns Colitis 2014;8:392–397.
  • Published: 2015-09-21

    Issue: Vol 2 No 6 (2015) (view)

    Section: Articles

    How to cite:
    Lopez Aparicio, A., García-Espona-Pancorbo, A., Clavero-Olmos, M., Muñoz-Roldán, I., & del Castillo-Rueda, A. (2015). Hepcidin and Ferritin Levels in Fever of Unknown Origin: Is There a New Biomarker?. European Journal of Case Reports in Internal Medicine, 2(6). https://doi.org/https://doi.org/10.12890/2015_000240