Schwannoma of the Lower Leg with Malignant Transformation. A Case Report

  • Oana Serban University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca
  • Laura Irina Poanta University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca
  • Florin Mihaileanu University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca
  • Daniela Fodor University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca


Schwannoma, malignant transformation, MPNST, malignant peripheral nerve sheath tumor


Background: Peripheral nerve sheath tumours are benign or malignant. Schwannoma is a benign peripheral nerve sheath tumour originating from Schwann cells that slowly grows eccentrically to the nerve axis. Malignant transformation of a schwannoma is rare.

Case presentation: A 73-year-old woman who presented to our medical service with other medical problems was diagnosed with a tumour of the lower leg (a small mass neglected by the patient for about 10 years). The ultrasound features of the tumour suggested it was a schwannoma. The tumour was resected and histopathological assessment revealed a schwannoma with areas of malignant peripheral nerve sheath tumour transformation.



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  • Published: 2015-07-31

    Issue: Vol 2 No 5 (2015) (view)

    Section: Articles

    How to cite:
    Serban, O., Poanta, L. I., Mihaileanu, F., & Fodor, D. (2015). Schwannoma of the Lower Leg with Malignant Transformation. A Case Report. European Journal of Case Reports in Internal Medicine, 2(5).