Efficacy of Rituximab on Rheumatoid Leptomeningitis as the First Symptom of Rheumatoid Arthritis
  • Mickaël Chouk
    Service de Rhumatologie, CHRU Besançon, Besançon, France
  • Alexandre Halb
    Service de Neurologie, CHRU Besançon, Besançon, France
  • Christine Mekhail
    Service de Rhumatologie, CHRU Besançon, Besançon, France
  • Amélie Godot
    Service de Médecine Interne, CHRU Besançon, Besançon, France
  • Frank Verhoeven
    Service de Rhumatologie, CHRU Besançon, Besançon, France
  • Clément Prati
    Service de Rhumatologie, CHRU Besançon, Besançon, France
  • Daniel Wendling
    Service de Rhumatologie, CHRU Besançon, Besançon, France

Keywords

Rheumatoid arthritis, rheumatoid meningitis, rituximab, leptomeningitis, seizure

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized mainly by arthritis, with the possible occurrence of extra-articular manifestations. We report the case of a patient who developed leptomeningitis as the first sign of RA, one year before the diagnosis of RA. Methylprednisolone 1000 mg was given intravenously. Because of the onset of seizures and cognitive impairment, rituximab was started. After three cycles of rituximab (1000 mg on day 0 and 1000 mg on day 15, every 6 months), neurological clinical examination, MRI and electroencephalogram findings were significantly improved.

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    Published: 2021-04-21
    Issue: 2021: Vol 8 No 4 (view)


    How to cite:
    1.
    Chouk M, Halb A, Mekhail C, Godot A, Verhoeven F, Prati C, Wendling D. Efficacy of Rituximab on Rheumatoid Leptomeningitis as the First Symptom of Rheumatoid Arthritis. EJCRIM 2021;8 doi:10.12890/2021_002358.