Crohn’s Disease with Atypical Extra-Intestinal Manifestations Developing Under Treatment with Vedolizumab

  • Aasem Abu Shtaya epartment of Internal Medicine “B”, Lady Davis Carmel Medical Center, Haifa, Israel; Technion – Israel Institute of Technology, The B. Rappaport Faculty of Medicine, Haifa, Israel
  • Shai Cohen Department of Internal Medicine “B”, Lady Davis Carmel Medical Center, Haifa, Israel; Technion – Israel Institute of Technology, The B. Rappaport Faculty of Medicine, Haifa, Israel
  • Yana Kogan Technion – Israel Institute of Technology, The B. Rappaport Faculty of Medicine, Haifa, Israel; Pulmonology Institute and CF center, Lady Davis Carmel Medical Center, Haifa, Israel
  • Michal Shteinberg Technion – Israel Institute of Technology, The B. Rappaport Faculty of Medicine, Haifa, Israel; Pulmonology Institute and CF center, Lady Davis Carmel Medical Center, Haifa, Israel
  • Ori Sagol Technion – Israel Institute of Technology, The B. Rappaport Faculty of Medicine, Haifa, Israel; Department of Gastroenterology, Lady Davis Carmel Medical Center, Haifa, Israel
DOI: https://doi.org/10.12890/2021_002265

Keywords

Crohn’s disease, granuloma, vedolizumab, infliximab

Abstract

Crohn’s disease is a chronic inflammatory bowel disease that can affect any part of the GI tract, which is frequently associated with extra-intestinal manifestations. Pulmonary parenchymal disease is very uncommon and usually considered to be debilitating and harder to diagnose. Pulmonary granulomas are rarely described in the literature as a complication of Crohn’s disease. Here, we present a patient with Crohn’s disease exacerbation who developed granulomatous lung disease under treatment with vedolizumab. Our case may add evidence to the emerging theory that gut-selective biologic agents could lead to upregulation of some pro-inflammatory factors leading to the evolution of pulmonary disease.

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    • Published: 2021-02-19

    Issue: 2021: Vol 8 No 2 (view)

    Section: Articles

    How to cite:
    1.
    Abu Shtaya A, Cohen S, Kogan Y, Shteinberg M, Sagol O. Crohn’s Disease with Atypical Extra-Intestinal Manifestations Developing Under Treatment with Vedolizumab. EJCRIM 2021;8 doi:10.12890/2021_002265.

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