Clear Cell Carcinoma of the Thymus: An Improbable Enemy

  • Fábio Rêgo Salgueiro Medical Oncology Department, Portuguese Oncology Institute of Coimbra Francisco Gentil, Coimbra, Portugal https://orcid.org/0000-0002-8243-6750
  • Paulo Cunha Internal Medicine Department, Coimbra University Hospital Centre, Coimbra, Portugal
  • Diana Miranda Medical Oncology Department, Portuguese Oncology Institute of Coimbra Francisco Gentil, Coimbra, Portugal
  • Tatiana Pereira Medical Oncology Department, Portuguese Oncology Institute of Coimbra Francisco Gentil, Coimbra, Portugal
  • Filipa Pontes Medical Oncology Department, Portuguese Oncology Institute of Coimbra Francisco Gentil, Coimbra, Portugal
  • Ana Caetano Medical Oncology Department, Portuguese Oncology Institute of Coimbra Francisco Gentil, Coimbra, Portugal
  • Joana Monteiro Medical Oncology Department, Portuguese Oncology Institute of Coimbra Francisco Gentil, Coimbra, Portugal

Keywords

Thymic carcinoma, mediastinal tumour

Abstract

Introduction: Thymic clear cell carcinoma is the most uncommon subtype of thymic carcinoma, with 20 cases reported worldwide.
Case Description: We present the case of a 61-year-old female with dyspnoea and chest pain for 2 days. Computed tomography (CT) angiography showed pulmonary thromboembolism and the existence of mediastinal and bilateral hilar lymphadenopathy, the largest infracarinal with an inferior axis of 25 mm, and also, micronodules on the left pulmonary parenchyma. The patient was admitted for aetiological assessment and underwent anticoagulant therapy. After a month, she had an ischaemic stroke, the sequelae of which proved to be fatal. The autopsy showed a mass in the superior-anterior mediastinum, with dimensions of 11×8×6 cm, corresponding to a thymus signet ring cell primary carcinoma. The immunohistochemistry study revealed that this mass was positive for AE1/AE3, CK5/6 and CK7.
Conclusion: The clinical, morphological and immunophenotypic diversity of this tumour makes its diagnosis a difficult multidisciplinary challenge, which requires a high level of clinical knowledge and accurate imaging and histological investigation.

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References

  • Dai X, Zhao L, Peng F. Primary clear cell carcinoma of the thymus and literature comparison of features. Cancer Manag Res 2018;10513–518.
  • Lale SA, Tiscornia-Wasserman PG, Aziz M. Diagnosis of thymic clear cell carcinoma by cytology. Case Rep Pathol 2013;2013:617810.
  • Moran CA, Suster S. Thymic carcinoma: current concepts and histologic features. Hematol Oncol Clin North Am 2008;22(3):393–407.
  • Lucchi M, Mussi A, Basolo F, Ambrogi MC, Fontanini G, Angeletti CA. The multimodality treatment of thymic carcinoma. Eur J Cardiothorac Surg 2001;19(5):566–569.
  • Hasserjian RP, Klimstra DS, Rosai J. Carcinoma of the thymus with clear-cell features. Report of eight cases and review of the literature. Am J Surg Pathol 1995;19(7):835–841.
  • Hsu YH. Clear cell carcinoma of the thymus. Tzu Chi Med J 2011;23(4):151–152.
  • Litvak AM, Woo K, Hayes S, Huang J, Rimner A, Sima CS, et al. Clinical characteristics and outcomes for patients with thymic carcinoma: evaluation of Masaoka staging. J Thorac Oncol 2014;9(12):1810–1815.
  • Published: 2021-02-26

    Issue: 2021: Vol 8 No 2 (view)

    Section: Articles

    How to cite:
    1.
    Rêgo Salgueiro F, Cunha P, Miranda D, Pereira T, Pontes F, Caetano A, Monteiro J. Clear Cell Carcinoma of the Thymus: An Improbable Enemy . EJCRIM 2021;8 doi:10.12890/2021_002224.

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