TAFRO Syndrome in a Patient of South-American Descent

  • Paola Finocchietto Department of Internal Medicine, Hospital de Clínicas José de San Martín, University of Buenos Aires
  • Damián Contardo Department of Internal Medicine, Hospital de Clínicas José de San Martín, University of Buenos Aires
  • Tatiana Uehara Department of Internal Medicine, Hospital de Clínicas José de San Martín, University of Buenos Aires
  • Claudia Papini Department of Internal Medicine, Hospital de Clínicas José de San Martín, University of Buenos Aires
  • Natalia Deligiannis Department of Internal Medicine, Hospital de Clínicas José de San Martín, University of Buenos Aires
  • Enrique Darderes Department of Internal Medicine, Hospital de Clínicas José de San Martín, University of Buenos Aires
  • Augusto Castroagudin Department of Internal Medicine, Hospital de Clínicas José de San Martín, University of Buenos Aires
  • Cecilia Cabral Department of Pathology, Hospital de Clínicas José de San Martín, University of Buenos Aires
  • Horacio di Fonzo Department of Internal Medicine, Hospital de Clínicas José de San Martín, University of Buenos Aires

Keywords

Castleman disease, TAFRO syndrome

Abstract

A 31-year-old Caucasian woman of South-American descent was diagnosed with a variant of multicentric Castleman disease (MCD) that has been reported in Japan as Castleman-Kojima disease. This is a systemic inflammatory disorder known as TAFRO Syndrome which includes thrombocytopenia, polyserositis (ascites/pleural effusion), microcytic anemia, myelofibrosis, fever, renal dysfunction and organomegaly, with immunologic disorder, polyclonal hypergammaglobulinemia, and elevated levels of interleukin-6 (IL-6) and the vascular endothelial growth factor present in serum and/or effusions. Optimal therapies are not well established. The patient was treated with methylprednisolone and rituximab. Following the start of treatment, the patient has been asymptomatic for over 8 months.

This is one of only a few reports of TAFRO Syndrome in a non-Japanese patient.

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  • Published: 2015-07-14

    Issue: Vol 2 No 4 (2015) (view)

    Section: Articles

    How to cite:
    Finocchietto, P., Contardo, D., Uehara, T., Papini, C., Deligiannis, N., Darderes, E., Castroagudin, A., Cabral, C., & di Fonzo, H. (2015). TAFRO Syndrome in a Patient of South-American Descent. European Journal of Case Reports in Internal Medicine, 2(4). https://doi.org/https://doi.org/10.12890/000220