Generalized Lichen Planus-like Eruption Related to Trimebutine

  • Dimitra Koumaki Dermatology Department, University Hospital of Heraklion, Heraklion, Crete, Greece
  • Vasiliki Koumaki Microbiology Department, Medical School of Athens, Athens, Greece
  • Alexander Katoulis 2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, Medical School, “Attikon” General University Hospital, Athens, Greece
  • Sotirios Boumpoucheropoulos Medical Oncology Department, Agioi Anargyroi General Oncological Hospital of Kifissia, Athens, Greece
  • George Evangelou Dermatology Department, University Hospital of Heraklion, Heraklion, Crete, Greece
  • Maria Stefanidou Dermatology Department, University Hospital of Heraklion, Heraklion, Crete, Greece
  • Konstantinos Krasagakis Dermatology Department, University Hospital of Heraklion, Heraklion, Crete, Greece
DOI: https://doi.org/10.12890/2020_002103

Keywords

Trimebutine maleate, lichenoid drug eruption, lichen planus, cutaneous adverse reaction

Abstract

Trimebutine is a spasmolytic agent with antimuscarinic effects that is used for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility disorders. Lichenoid drug eruptions (LDE) to trimebutine maleate have not been previously reported. Here we present the case of a 50-year-old male patient who developed an extensive lichenoid eruption on his upper and lower extremities and trunk 4 weeks after starting treatment with trimebutine maleate 300 mg once daily for IBS. Two months after discontinuation of the drug and administration of topical treatment with emollients and corticosteroids, the LDE cleared completely with no recurrence. The diagnosis of LDE due to trimebutine was made, based upon the clinical features resembling lichen planus, the histological findings of interface dermatitis, the evidence of a temporal relationship between drug intake and the development of skin lesions, and resolution upon discontinuation of the drug. To the best of the authors’ knowledge, LDE following trimebutine maleate intake has not been previously reported. Management of trimebutine-induced LDE includes withdrawal of the causative agent and treatment with potent topical corticosteroids.

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    • Published: 2020-11-24

    Issue: Vol 7 No 12 (view)

    Section: Articles

    How to cite:
    1.
    Koumaki D, Koumaki V, Katoulis A, Boumpoucheropoulos S, Evangelou G, Stefanidou M, Krasagakis K. Generalized Lichen Planus-like Eruption Related to Trimebutine. EJCRIM 2020;7 doi:10.12890/2020_002103.

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