Skeletal Myopathy as the Initial Manifestation of Light Chain Multiple Myeloma
  • Mohamed Reda Belkhribchia
    Department of Neurology, Hassan II Regional Hospital, Dakhla, Morocco
  • Sara Moukhlis
    Pathologic Anatomy and Cytology Laboratory, University Hospital Center Ibn Rochd, Casablanca, Morocco
  • Tarik Bentaoune
    Department of Cardiology, Hassan II Regional Hospital, Dakhla, Morocco
  • Najat Chourkani
    Private Neurology Practice, Casablanca, Morocco
  • Mohamed Zaidani
    Department of Hematology, Ryad Oncologia Clinic, Casablanca, Morocco
  • Mehdi Karkouri
    Pathologic Anatomy and Cytology Laboratory, University Hospital Center Ibn Rochd, Casablanca, Morocco

Keywords

Light chain deposition disease, skeletal myopathy, light chain multiple myeloma, monoclonal immunoglobulin deposition disease, chemotherapy

Abstract

Monoclonal gammopathies due to plasma cell dyscrasias can cause various rare neuromuscular disorders. The peripheral nervous system is most commonly affected, while muscle diseases associated with monoclonal gammopathies are rare. Skeletal myopathy, as a manifestation in the context of multiple myeloma, is extremely uncommon and is usually the result of immunoglobulin light chain (AL) amyloidosis deposits in the muscles. Here we present an atypical case of a patient with generalized myopathy as the presenting manifestation of light chain multiple myeloma. Interestingly, muscle involvement in our case was not the consequence of AL amyloidosis deposits but rather due to non-amyloid light chain deposition disease associated with light chain multiple myeloma.

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    Published: 2020-11-20
    Issue: 2020: Vol 7 No 12 (view)

    How to cite:
    1.
    Belkhribchia MR, Moukhlis S, Bentaoune T, Chourkani N, Zaidani M, Karkouri M. Skeletal Myopathy as the Initial Manifestation of Light Chain Multiple Myeloma. EJCRIM 2020;7 doi:10.12890/2020_002095.

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