Treatment of Crimean-Congo Haemorrhagic Fever by Favipiravir in a Patient with Novel Coronavirus Co-Infection

  • Ahmet Cumhur Dülger Department of Gastroenterology, Giresun State Hospital Affiliated to Giresun University,Giresun, Turkey
  • Mustafa Yakarişik Department of Internal Medicine, Giresun State Hospital Affiliated to Giresun University,Giresun, Turkey
  • Yusuf Emre Uzun Department of Internal Medicine, Dereli State Hospital, Giresun, Turkey
  • Ahmet Melih Şahin Department of Infectious Disease, Giresun State Hospital Affiliated to Giresun University, Giresun, Turkey

Keywords

Crimean-Congo haemorrhagic fever, COVID-19, favipiravir

Abstract

Introduction: Crimean-Congo haemorrhagic fever (CCHF) is a lethal zoonotic disease caused by an RNA virus that is a member of the Nairovirus genus in the Bunyaviridae family from the arbovirus group. CCHF is transmitted by Hyalomma ticks through direct contact with the blood and other bodily fluids of patients or infected animals.

Case description: A 65-year-old man was admitted to the emergency unit with dry cough, myalgia and fever. He was treated with favipiravir. He had disseminated intravascular coagulopathy with thrombocytopenia in the setting of COVID-19 infection. He tested positive for both COVID-19 and CCHF. By the end of the fifth day of treatment, his laboratory parameters and clinical symptoms had normalized.

Conclusion: Favipiravir is currently on the market for treating COVID-19 infection worldwide. It has also been used to treat CCHF in laboratory animals. To the best of our knowledge this is the first report of CCHF successfully treated with favipiravir, which could be a key drug for treating human CCHF.

Author Biographies

Yusuf Emre Uzun ,
Department of Internal Medicine, Dereli State Hospital, Giresun, Turkey

Department of Internal Medicine

Ahmet Melih Şahin ,
Department of Infectious Disease, Giresun State Hospital Affiliated to Giresun University, Giresun, Turkey

Department of Infectious Disease

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  • Published: 2020-12-17

    Issue: Vol 7 No 12 (view)

    Section: Articles

    How to cite:
    1.
    Dülger AC, Yakarişik M, Uzun YE, Şahin AM. Treatment of Crimean-Congo Haemorrhagic Fever by Favipiravir in a Patient with Novel Coronavirus Co-Infection. EJCRIM 2020;7 doi:10.12890/2020_002042.

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