Hyperemesis Gravidarum: A Benign Condition of Pregnancy or a Challenging Metabolic Disorder?

  • Matilda Florentin Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
  • Ioannis Parthymos Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
  • Aris Agouridis School of Medicine, European University Cyprus, Nicosia, Cyprus
  • George Liamis Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece

Keywords

Acute kidney injury, alkalemia, hepatitis, hyperemesis gravidarum, hypokalemia, hyponatremia, hypovolemia

Abstract

Hyperemesis gravidarum (HG) is a complication mainly of the first trimester of pregnancy, which sometimes leads to metabolic disorders such as hypovolemia and acute kidney injury (AKI). Herein, we present the case of a 25-year-old woman at week 10 of gestation who exhibited a constellation ofsevere abnormalities, namely AKI (serum creatinine 6.15 mg/dl), transaminasemia (serum aminotransferases >1,000 IU/l), alkalemia (arterial pH7.667), hyponatremia (serum sodium 117 mEq/l), hypochloremia (serum chloride 54 mEq/l),hypokalemia (serum potassium 2.2 mEq/l) and hyperuricemia (serum uric acid 20 mg/dl). Despite a thorough work-up, no other disorder was found apart from HG. All symptoms and metabolic abnormalities resolved with targeted administration of intravenous fluids. The differential diagnosis of these disorders and therapeutic challenges are discussed.

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Published: 2020-10-16

Issue: LATEST ONLINE (view)

Section: Articles

How to cite:
1.
Florentin M, Parthymos I, Agouridis A, Liamis G. Hyperemesis Gravidarum: A Benign Condition of Pregnancy or a Challenging Metabolic Disorder?. EJCRIM 2020;2 doi:10.12890/2020_001979.