Propofol-Induced Hepatitis
  • Hanna Raisi
    Center for Alcohol Research (CAR), University of Heidelberg and Department of Medicine, Salem Medical Center, Heidelberg, Germany
  • Thomas Longerich
    Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany
  • Bernardo Moreira Assuncao
    Center for Alcohol Research (CAR), University of Heidelberg and Department of Medicine, Salem Medical Center, Heidelberg, Germany
  • Sebastian Mueller
    Center for Alcohol Research (CAR), University of Heidelberg and Department of Medicine, Salem Medical Center, Heidelberg, Germany
  • Peter Schirmacher
    Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany
  • Helmut-Karl Seitz
    Center for Alcohol Research (CAR), University of Heidelberg and Department of Medicine, Salem Medical Center, Heidelberg, Germany

Keywords

Propofol, hepatitis, anaesthesia

Abstract

Objectives:To present a rare case of propofol-induced hepatitis.
Materials and methods: A 59-year old man was referred to our department because of suspicion of toxic hepatitis after propofol anaesthesia for endoscopic colonoscopy. 
Results: The patient had jaundice, increased transaminases demonstrating liver necrosis, and liver stiffness of 18 kPa. Liver biopsy revealed bridging necrosis and initial post-collapse fibrosis. Following therapy with steroids and N-acetyl cysteine, the patient was discharged on the seventh day after admission in good general condition.
Conclusion: Although propofol is considered safe, it can cause acute hepatitis, the seventh published case of which is reported here. Importantly, treatment with N-acetyl cysteine, a radical scavenger, but especially with steroids resulted in hepatic improvement.

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    Published: 2020-10-08
    Issue: 2020: Vol 7 No 12 (view)


    How to cite:
    1.
    Raisi H, Longerich T, Moreira Assuncao B, Mueller S, Schirmacher P, Seitz H-K. Propofol-Induced Hepatitis. EJCRIM 2020;7 doi:10.12890/2020_001921.