Psychiatric Manifestations of Sporadic Creutzfeldt-Jakob Disease Simulate Depressive Disorder with Psychotic Symptoms
  • Joana Almeida Espírito Santo
    Internal Medicine Department, University Hospital Center of Coimbra, Coimbra
  • Rui Garcia
    Internal Medicine Department, University Hospital Center of Coimbra, Coimbra
  • Rui Marques dos Santos
    Internal Medicine Department, University Hospital Center of Coimbra, Coimbra
  • João Lemos
    Neurology Department, University Hospital Center of Coimbra, Coimbra
  • Isabel Santana
    Neurology Department, University Hospital Center of Coimbra, Coimbra

Abstract

Creutzfeldt–Jakob disease (CJD) is a rare and fatal neurodegenerative disorder with a broad spectrum of early clinical manifestations, comprising neurological and psychiatric symptoms. The authors report the case of a patient admitted with a diagnosis of depressive disorder with psychotic symptoms, with post-mortem confirmation of CJD and discuss how CJD’s clinical heterogeneity can lead to misdiagnosis of the disease. Despite CJD’s unique pathogenesis, its kaleidoscopic presentation justifies the integrated investigation of patients with psychiatric symptoms, avoiding restrictive diagnosis.

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    Published: 2015-03-10
    Issue: Vol. 2 No. 1 (2015) (view)

    How to cite:
    1.
    Espírito Santo JA, Garcia R, Marques dos Santos R, Lemos J, Santana I. Psychiatric Manifestations of Sporadic Creutzfeldt-Jakob Disease Simulate Depressive Disorder with Psychotic Symptoms. EJCRIM 2015;2 doi:10.12890/2015_000189.

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