Spontaneous Periodic Hypothermia in the Elderly: A Rare or Under-Recognised Syndrome

  • Hassene Attout Internal Medicine Unit, General Hospital, Ales, France
  • Sofia Amichi Internal Medicine Unit, General Hospital, Ales, France
  • Youcef Belkheir Internal Medicine Unit, General Hospital, Ales, France

Keywords

Periodic hypothermia, Shapiro’s syndrome, clomipramine

Abstract

Spontaneous periodic hypothermia is a rare syndrome presenting with recurrent, centrally mediated hypothermia without an identifiable systemic cause or brain lesion. The case of an 88-year-old woman with recurrent hypothermia is reported. Despite intensive investigation, no other manifestations of hypothalamic or autonomic dysfunction were found. No corpus callosum lesion was seen on MRI. The patient was successfully treated with clomipramine chlorhydrate.

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References

  • Shapiro WR, Williams GH, Plum F. Spontaneous recurrent hypothermia accompanying agenesis of the corpus callosum. Brain 1969;92:423–436.
  • Blondin NA. Diagnosis and management of periodic hypothermia. Neurol Clin Pract 2014;4(1):26–32.
  • Kloos RT. Spontaneous periodic hypothermia. Medicine (Baltimore) 1995;74(5):268–280.
  • Bosacki C, Hausfater P, Koenig M, Serratrice J, Piette AM, Cathebras P. Spontaneous hypothermia: a series of ten cases, place of Shapiro’s syndrome. Rev Med Interne 2005;26(8):615–623.
  • Mayer U, Aigner JM, Klein HE. Hypothermia caused by neuroleptics: 2 case reports and review of the literature. Nervenarzt 1994;65(7):488–491.
  • Hemelsoet DM, De Bleecker JL. Post-traumatic spontaneous recurrent hypothermia: a variant of Shapiro’s syndrome. Eur J Neurol 2007;14(2):224–227.
  • Walker BR, Anderson JA, Edwards CR. Clonidine therapy for Shapiro’s syndrome. Q J Med 1992;82(299):235–245.
  • Rodrigues MM, Lin J, Arita JH, De Castro Neto EF, Scerni DA, Cavalheiro EA, et al. Spontaneous periodic hypothermia and hyperhidrosis: a possible novel cerebral neurotransmitter disorder. Dev Med Child Neurol 2011;53:378–380.
  • Tambasco N, Belcastro V, Prontera P, Nigro P, Donti E, Rossi A, et al. Shapiro's syndrome: defining the clinical spectrum of the spontaneous paroxysmal hypothermia syndrome. Eur J Paediatr Neurol 2014;18:453–457.
  • Published: 2020-09-28

    Issue: Vol 7 No 12 (view)

    Section: Articles

    How to cite:
    1.
    Attout H, Amichi S, Belkheir Y. Spontaneous Periodic Hypothermia in the Elderly: A Rare or Under-Recognised Syndrome. EJCRIM 2020;7 doi:10.12890/2020_001874.