Spontaneous Periodic Hypothermia in the Elderly: A Rare or Under-Recognised Syndrome
  • Hassene Attout
    Internal Medicine Unit, General Hospital, Ales, France
  • Sofia Amichi
    Internal Medicine Unit, General Hospital, Ales, France
  • Youcef Belkheir
    Internal Medicine Unit, General Hospital, Ales, France


Periodic hypothermia, Shapiro’s syndrome, clomipramine


Spontaneous periodic hypothermia is a rare syndrome presenting with recurrent, centrally mediated hypothermia without an identifiable systemic cause or brain lesion. The case of an 88-year-old woman with recurrent hypothermia is reported. Despite intensive investigation, no other manifestations of hypothalamic or autonomic dysfunction were found. No corpus callosum lesion was seen on MRI. The patient was successfully treated with clomipramine chlorhydrate.



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    Published: 2020-09-28
    Issue: 2020: Vol 7 No 12 (view)

    How to cite:
    Attout H, Amichi S, Belkheir Y. Spontaneous Periodic Hypothermia in the Elderly: A Rare or Under-Recognised Syndrome. EJCRIM 2020;7 doi:10.12890/2020_001874.