SARS-CoV-2 Infection with Associated Rhabdomyolysis and Probable Myocarditis

  • Franco Murillo Clínica Anglo-Americana, Lima, Perù
  • Gastón Ramos Clínica Anglo-Americana, Lima, Perù
  • Jose Luis Del Pozo Clinica Universidad de Navarra, Pamplona, Spain
  • Luis Manuel Valdez Clínica Anglo-Americana, Lima, Peru; Facultad de Medicina Humana, Universidad de Piura, Lima, Peru; Departamento de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru
  • Jorge Zagaceta Clínica Anglo-Americana, Lima, Peru; Departamento de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru
DOI: https://doi.org/10.12890/2020_001867

Keywords

SARS-CoV-2, rhabdomyolysis, myocarditis

Abstract

We describe a patient with SARS-CoV-2 and severe pneumonia who required mechanical ventilation and developed associated rhabdomyolysis with probable myocardial involvement as evidenced by cardiac enzyme abnormalities and echocardiographic findings. Repeat testing should be done in cases highly suspicious for SARS-CoV-2 as initial molecular tests may be negative, as in our case.

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References

  • Velavan TP, Meyer CG. The COVID-19 epidemic. Trop Med Int Health 2020;25:278–280.
  • Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497–506.
  • Wang Q, Zhang Y, Wu L, Niu S, Song C, Zhang Z, et al. Structural and functional basis of SARS-CoV-2 entry by using human ACE2. Cell 2020;181(4):894–904.e9.
  • Lai C-C, Liu YH, Wang C-Y, Wang Y-H, Hsueh S-C, Yen M-Y, et al. Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): facts and myths. J Microbiol Immunol Infect 2020;53(3):404–412.
  • Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395:1054–1062.
  • Zutt R, van der Kooi AJ, Linthorst GE, Wanders RJA, de Visser M. Rhabdomyolysis: review of the literature. Neuromuscul Disord 2014;24:651–659.
  • Wu V-C, Hsueh P-R, Lin W-C, Huang J-W, Tsai H-B, Chen Y-M, et al. Acute renal failure in SARS patients: more than rhabdomyolysis. Nephrol Dial Transplant 2004;19:3180–3182.
  • Feng Y, Ling Y, Bai T, Xie Y, Huang J, Li J, et al. COVID-19 with different severity: a multi-center study of clinical features. Am J Respir Crit Care Med 2020;201(11):1380–1388.
  • Hsiao C-H, Chang M-F, Hsueh P-R, Su I-J. Immunohistochemical study of severe acute respiratory syndrome-associated coronavirus in tissue sections of patients. J Formos Med Assoc 2005;104:150–156.
  • Hamel Y, Mamoune A, Mauvais F-X, Habarou F, Lallement L, Romero NB, et al. Acute rhabdomyolysis and inflammation. J Inherit Metab Dis 2015;38:621–628.
  • Pollack A, Kontorovich AR, Fuster V, Dec GW. Viral myocarditis--diagnosis, treatment options, and current controversies. Nat Rev Cardiol 2015;12:670–680.
  • Fung G, Luo H, Qiu Y, Yang D, McManus B. Myocarditis. Circ Res 2016;118:496–514.

    • Published: 2020-08-19

    Issue: Vol 7 No 9 (view)

    Section: Articles

    How to cite:
    1.
    Murillo F, Ramos G, Del Pozo JL, Valdez LM, Zagaceta J. SARS-CoV-2 Infection with Associated Rhabdomyolysis and Probable Myocarditis. EJCRIM 2020;7 doi:10.12890/2020_001867.