Multi-Focal Splenic Tumour in a Belgian Patient and a Brief Review of the Literature on Littoral Cell Angioma
KeywordsLittoral cell tumour, spleen, CT scan, immunohistochemistry
We describe the case of a 66-year-old woman with littoral cell angioma (LCA) confirmed by histopathology and immunohistochemistry, to our knowledge the first case in Belgium. LCA is an extremely rare primary vascular tumour of the splenic red pulp, probably originating from littoral cells. If a splenic mass and nodules are incidentally identified on imaging and the patient has no associated signs or symptoms, LCA should be suspected. Histopathology and adjacent techniques are mandatory for definitive diagnosis. Splenectomy followed by adequate follow-up is necessary to exclude underlying pathology.
Falck S, Stutte HJ, Frizzera G. Littoral cell angioma. A novel splenic vascular lesion demonstrating histiocytic differentiation. Am J Surg Pathol 1991;15:1023–1033.
Peckova K, Michal M, Hadravsky L, Suster S, Damjanov I, Miesbauerova M, et al. Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies. Histopathology 2016;69(5):762–774.
Liu Z, Zhu J, Peng L, Tu Y, Li Y, Xiao W. Littoral cell angioma of the spleen: three cases report and literature review. Int J Clin Exp Med 2018;11(2):1077–1081.
Shweta B, Jiaoti H, Vikram D. Littoral cell angioma of the spleen. Am J Roentgenol2007;188:1365–1366.
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