Asymptomatic Hyperinsulinaemic Hypoglycaemia
  • Ana Ferreira
    Department of Internal Medicine, Centro Hospitalar Universitário de São João, Porto, Portugal http://orcid.org/0000-0002-7013-3664
  • Mariana Serino Barbosa
    Department of Pneumology, Centro Hospitalar Universitário de São João, Porto, Portugal
  • Rita Coelho
    Department of Anatomopathology, Centro Hospitalar Universitário de São João, Porto, Portugal
  • Patrícia Lourenço
    Department of Internal Medicine, Centro Hospitalar Universitário de São João, Porto, Portugal

Keywords

Endogenous hyperinsulinism, hyperinsulinemic hypoglycemia, malignant insulinoma, hypoglycemia unawareness

Abstract

Hypoglycaemia is rare in apparently well patients without drug-treated diabetes mellitus and warrants evaluation and management when Whipple’s triad is present. Even in the absence of Whipple’s triad, when repeatedly low values of plasma glucose are documented, the presence of endogenous hyperinsulinism should be investigated. The authors describe a case of endogenous hypoglycaemic hyperinsulinism, its diagnosis and treatment and the challenges of determining its aetiology.

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References

  • Kittah NE, Vella A. Management of endocrine disease: pathogenesis and management of hypoglycemia. Eur J Endocrinol 2017;177(1):R37–R47.
  • Challis BG, Powlson AS, Casey RT, Pearson C, Lam BY, Ma M, et al. Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice: diagnosis, aetiology and management. Endocr Connect 2017;6(7):540–548.
  • Cryer PE, Axelrod L, Grossman AB, Heller SR, Montori VM, Seaquist ER, et al. Evaluation and management of adult hypoglycemic disorders: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2009;94(3):709–728.
  • Martín-Timón I, Cañizo-Gómez FJ. Mechanisms of hypoglycemia unawareness and implications in diabetic patients. World J Diabetes 2015;6(7):912–926.
  • Herbel G, Boyle P. Hypoglycemia: pathophysiology and treatment. Endocrinol Metab Clin North Am 2000;29(4):725–743.

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    Published: 2020-07-24
    Issue: 2020: Vol 7 No 10 (view)

    How to cite:
    1.
    Ferreira A, Barbosa MS, Coelho R, Lourenço P. Asymptomatic Hyperinsulinaemic Hypoglycaemia. EJCRIM 2020;7 doi:10.12890/2020_001827.

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