Mondor's Disease in SARS-CoV-2 Infection: A Case of Superficial Vein Thrombosis in the Era of COVID-19

  • Gianfranco Lessiani Angiology Unit, Department of Internal Medicine, “Villa Serena” Hospital, Città Sant’Angelo, Italy
  • Andrea Boccatonda Internal Medicine, Department of Medicine and Aging Science, “G. D’Annunzio” University of Chieti, Chieti, Italy
  • Damiano D'Ardes Internal Medicine, Department of Medicine and Aging Science, “G. D’Annunzio” University of Chieti, Chieti, Italy
  • Giulio Cocco Internal Medicine, Department of Medicine and Aging Science, “G. D’Annunzio” University of Chieti, Chieti, Italy
  • Giuseppe Di Marco Urology Unit, Department of General Surgery, “Villa Serena” Hospital, Città Sant’Angelo, Italy
  • Cosima Schiavone Internal Medicine, Department of Medicine and Aging Science, “G. D’Annunzio” University of Chieti, Chieti, Italy

Keywords

COVID-19, SARS-CoV-2, vein thrombosis, Mondor’s disease

Abstract

SARS-CoV-2 causes blood hypercoagulability and severe inflammation resulting in an increased risk of thrombosis. Consequently, COVID-19 patients with cardiovascular disease seem to be at higher risk of adverse events. Mondor’s disease is a rare, generally self-limiting, thrombosis of the penis. The pathogenesis of Mondor’s disease is unknown, and it is usually diagnosed through clinical signs and with Doppler ultrasound evaluation. We describe the case of a young man with COVID-19 infection who manifested Mondor’s disease.

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References

Huang C. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395(10223):497–506.

Weiss P, Murdoch DR. Clinical course and mortality risk of severe COVID-19. Lancet 2020;395(10229):1014–1015.

D'Ardes D, Boccatonda A, Rossi I, Guagnano MT, Santilli F, Cipollone F, et al. COVID-19 and RAS: unravelling an unclear relationship. Int J Mol Sci 2020;21(8):E3003.

Levi M, Thachil J, Iba T, Levy JH. Coagulation abnormalities and thrombosis in patients with COVID-19. Lancet Haematol 2020;7(6):e438–e440.

Xiong TY, Redwood S, Prendergast B, Chen M. Coronaviruses and the cardiovascular system: acute and long-term implications. Eur Heart J 2020;41(19):1798–1800.

Driggin E, Madhavan MV, Bikdeli B, Chuich T, Laracy J, Biondi-Zoccai G, et al. Cardiovascular considerations for patients, health care workers, and health systems during the coronavirus disease 2019 (COVID-19) pandemic. J Am Coll Cardiol 2020;75(18):2352–2371.

Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Potential effects of coronaviruses on the cardiovascular system: a review. JAMA Cardiol 2020 Mar 27. doi: 10.1001/jamacardio.2020.1286 [Epub ahead of print].

Barnes GD, Burnett A, Allen A, Blumenstein M, Clark NP, Cuker A, et al. Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum. J Thromb Thrombolysis 2020;50(1):72–81.

Mondor H. Tronculite sous-cutanèe subaigue de la paroi thoragigue antèro-lateral. Mem Acad Chir 1939;65:1271–1278.

Liden-Castro E, Pelayo-Nieto M, Ramirez-Galindo I, Espinosa-Perezgrovas D, Cornejio-Davila V, Rubio-Arellano E. Mondor disease: thrombosis of the dorsal vein of the penis. Urol Case Rep 2018;19:34–35.

Kumar B, Narag T, Radotra BD, Gupta S. Mondor's disease of penis: a forgotten disease. Sex Transm Infect 2005;81:480–482.

Al-Mwalad M, Loertzer H, Wicht A, Fornara P. Subcutaneous penile vein thrombosis (penile Mondor's disease): pathogenesis, diagnosis, and therapy. Urology 2006;67:586–588.

Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, et al. Endothelial cell infection and endothelitis in Covid-19. Lancet 2020;395(10234):1417–1418.

Cui S, Chen S, Li X, Liu S, Wang F. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost 2020;18(6):1421–1424.

Boccatonda A, Ianniello E, D’Ardes D, Cocco G, Giostra F, Borghi C, et al. Can lung ultrasound be used to screen for pulmonary embolism in patients with SARS-CoV-2 pneumonia? Eur J Case Rep Intern Med 2020;7(7):001748.

Klok FA, Kruip MJHA, van der Meer NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res 2020;191:145-147. doi:10.1016/j.thromres.2020.04.013.

Lodigiani C, Iapichino G, Carenzo L, Cecconi M, Ferrazzi P, Sebastian T, et al. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res 2020;191:9–14.

Published: 2020-09-01

Issue: Vol 7 No 10 (view)

Section: Articles

How to cite:
1.
Lessiani G, Boccatonda A, D’Ardes D, Cocco G, Di Marco G, Schiavone C. Mondor’s Disease in SARS-CoV-2 Infection: A Case of Superficial Vein Thrombosis in the Era of COVID-19. EJCRIM 2020;7 doi:10.12890/2020_001803.

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