Subungual Squamous Cell Carcinoma in a Patient with Psoriasis

Sherif Monib; Kevin Seebah

doi:10.12890/2020_001788

Subungual Squamous Cell Carcinoma in a Patient with Psoriasis

Sherif Monib General Surgery Department, West Hertfordshire Hospitals NHS Trust, St Albans, UK
Kevin Seebah West General Surgery Department, West Hertfordshire Hospitals NHS Trust, St Albans, UK

DOI: https://doi.org/10.12890/2020_001788

Keywords

Subungual squamous cell carcinoma, psoriasis, PUVA, cyclosporine

Abstract

Subungual squamous cell carcinoma (SCC) is a rare malignant tumour with an indolent course and unknown aetiology. It is usually misdiagnosed as a benign lesion, resulting in delayed treatment. Although psoriasis is not a precancerous skin condition, the treatment modalities cyclosporine and psoralen with ultraviolet A (PUVA) might increase the risk of developing cutaneous SCC, although a relationship has not been confirmed.
We describe a patient with psoriasis who had been treated with cyclosporine and PUVA 6 years previously. He developed back SCC 2 years later, a subungual skin lesion after another 2 years and presented to us 1 year later, when nail elevation and biopsy revealed SCC.

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References

Wong TC, Ip FK, Wu WC. Squamous cell carcinoma of the nail bed: three case reports. J Orthop Surg (Hong Kong) 2004;12(2):248–252.

Pegas JR, Fernandes KKML, do Prado IDF, de Souza Bazzo ILM, Tebcherani AJ, Cade KV. Subungual squamous cell carcinoma: case report and literature review. Surg Cosmet Dermatol 2010;2(4):316–318.

Alam M, Ratner D. Cutaneous squamous-cell carcinoma. N Engl J Med 2001;344:975–983.

Yip KM, Lam SL, Shee BW, Shun CT, Yang RS. Subungual squamous cell carcinoma: report of 2 cases. J Formos Med Assoc 200099:646–649.

Lecerf P, Richert B, Theunis A, André J. A retrospective study of squamous cell carcinoma of the nail unit diagnosed in a Belgian general hospital over a 15-year period. J Am Acad Dermatol 2013;69:253–261.

Riddel C, Rashid R, Thomas V. Ungual and periungual human papillomavirus-associated squamous cell carcinoma: a review. J Am Acad Dermatol 2011;64:1147–1153.

Dalle S, Depape L, Phan A, Balme B, Ronger-Savle S, Thomas L. Squamous cell carcinoma of the nail apparatus: clinicopathological study of 35 cases. Br J Dermatol 2007;156(5):871–874.