An Unusual Case of Allergic Reaction to Anakinra in a Patient with Tumor Necrosis Factor Receptor-1 Associated Periodic Syndrome (TRAPS) and Subsequent Canakinumab Treatment

  • Marta Mejias Trueba Pharmacy Service, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío, Seville, Spain
  • Marta Alonso Moreno Pharmacy Service, Hospital Universitario Virgen del Rocío, Seville, Spain
  • Noemi Garrido Puñal Rheumatology Service, Hospital Universitario Virgen del Rocío, Seville, Spain
  • Maria Soriano Martinez Pharmacy Service, Hospital Universitario Virgen del Rocío, Seville, Spain

Keywords

TRAPS syndrome, anakinra, allergic reaction, canakinumab

Abstract

Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is a rare hereditary systemic autoinflammatory disease (SAID). Treatment is based on corticosteroids, but often requires the addition of a biologic drug (anti-TNF agent, IL-1 receptor antagonist, etc) to achieve symptom control. The addition of the second drug is not clearly defined and must take into account the characteristics and preferences of the patient. We describe a patient with TRAPS and an allergic reaction to anakinra which was difficult to manage clinically while alternative treatment was being identified.

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Published: 2020-07-29

Issue: Vol 7 No 10 (view)

Section: Articles

How to cite:
1.
Mejias Trueba M, Alonso Moreno M, Garrido Puñal N, Soriano Martinez M. An Unusual Case of Allergic Reaction to Anakinra in a Patient with Tumor Necrosis Factor Receptor-1 Associated Periodic Syndrome (TRAPS) and Subsequent Canakinumab Treatment. EJCRIM 2020;7 doi:10.12890/2020_001668.