Acquired Haemophilia Associated with Urticarial Vasculitis

Hassene Attout

doi:10.12890/2020_001660

Acquired Haemophilia Associated with Urticarial Vasculitis

Hassene Attout Internal Medicine Unit, General Hospital Alés, Alés, France

DOI: https://doi.org/10.12890/2020_001660

Keywords

Haemophilia, urticarial vasculitis

Abstract

Acquired haemophilia (AHA) is a rare autoimmune disorder caused by circulating autoantibodies that inhibit the activity of factor VIII (FVIII). Acquired inhibitors against FVIII are rarely seen, with a reported incidence of approximately 1 case per million/year. Clinical conditions and contexts associated with AHA include autoimmune diseases, lymphoproliferative malignancies, drug treatment, pregnancy and infections. An association with urticarial vasculitis is even more rare. Here, we report a case of a 59-year-old woman presenting with cutaneous and muscle haematomas secondary to AHA in association with urticarial vasculitis, who was successfully treated with factor eight inhibitor bypassing activity (FEIBA) and prednisolone.

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