Non-Celiac Gluten Sensitivity and Autoimmunity. A Case Report.

  • Carlos Isasi Department of Rheumatology, Hospital Puerta de Hierro Majadahonda, Madrid
  • Isabel Colmenero Histopathology Department, Birmingham Children's Hospital, Birmingham
  • Fernando Casco Department of Pathology, Histiocitomed, Madrid
  • Eva Tejerina Department of Pathology, Hospital Puerta de Hierro Majadahonda, Madrid
  • Natalia Fernandez-Puga Department of Gastroenterology, Hospital Puerta de Hierro Majadahonda, Madrid


Coeliac disease, gluten sensitivity, autoimmunity


Introduction, objective: To present a case report in which the finding of non-coeliac gluten sensitivity was decisive for the treatment of a complex autoimmune disease.

Materials and methods: A 43-year-old woman with polyarthritis, psoriatic features, anti-SSA/Ro and anti-cyclic citrullinated peptide antibodies, with refractory course, was evaluated for gluten sensitivity despite negative serology for coeliac disease.

Results: The patient carried the HLA DQ2 haplotype and duodenal biopsy showed lymphocytic enteritis. A gluten-free diet resolved the clinical picture and permitted tapering of immunosuppressive therapy.

Conclusion: Non-coeliac gluten sensitivity can be associated with autoimmunity despite the absence of the specific autoantibodies of coeliac disease.



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  • Published: 2014-12-05

    Issue: Vol 1 (2014) (view)

    Section: Articles

    How to cite:
    Isasi, C., Colmenero, I., Casco, F., Tejerina, E., & Fernandez-Puga, N. (2014). Non-Celiac Gluten Sensitivity and Autoimmunity. A Case Report. European Journal of Case Reports in Internal Medicine, 1(1).