Non-Celiac Gluten Sensitivity and Autoimmunity. A Case Report.

  • Carlos Isasi Department of Rheumatology, Hospital Puerta de Hierro Majadahonda, Madrid
  • Isabel Colmenero Histopathology Department, Birmingham Children's Hospital, Birmingham
  • Fernando Casco Department of Pathology, Histiocitomed, Madrid
  • Eva Tejerina Department of Pathology, Hospital Puerta de Hierro Majadahonda, Madrid
  • Natalia Fernandez-Puga Department of Gastroenterology, Hospital Puerta de Hierro Majadahonda, Madrid

Keywords

Coeliac disease, gluten sensitivity, autoimmunity

Abstract

Introduction, objective: To present a case report in which the finding of non-coeliac gluten sensitivity was decisive for the treatment of a complex autoimmune disease.

Materials and methods: A 43-year-old woman with polyarthritis, psoriatic features, anti-SSA/Ro and anti-cyclic citrullinated peptide antibodies, with refractory course, was evaluated for gluten sensitivity despite negative serology for coeliac disease.

Results: The patient carried the HLA DQ2 haplotype and duodenal biopsy showed lymphocytic enteritis. A gluten-free diet resolved the clinical picture and permitted tapering of immunosuppressive therapy.

Conclusion: Non-coeliac gluten sensitivity can be associated with autoimmunity despite the absence of the specific autoantibodies of coeliac disease.

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References

  • Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH et al. The Oslo definitions for coeliac disease and related terms, Gut 2013;62:43–52.

  • Catassi C, Bai JC, Bonaz B, Bouma G, Calabrò A, Carrocio A et al. Non-celiac gluten sensitivity: the new frontier of gluten related disorders, Nutrients 2013;5:3839–3853.

  • Troncone R, Jabri B. Coeliac disease and gluten sensitivity, J. Intern. Med. 2011;269:582–590.

  • Molina-Infante J, Santolaria S, Fernandez-Bañares F, Montoro M, Esteve M. Lymphocytic enteropathy, HLA-DQ2/DQ8 genotype and wheat-dependent symptoms: non-celiac wheat sensitivity or Marsh I celiac disease? Am. J. Gastroenterol. 2013;108:451.

  • Isasi C, Colmenero I, Casco F, Tejerina E, Fernandez N, Serrano-Vela JI et al. Fibromyalgia and non-celiac gluten sensitivity: a description with remission of fibromyalgia, Rheumatol. Int. 2014;34:1607–1612.
  • Published: 2014-12-05

    Issue: Vol 1 (2014) (view)

    Section: Articles

    How to cite:
    Isasi, C., Colmenero, I., Casco, F., Tejerina, E., & Fernandez-Puga, N. (2014). Non-Celiac Gluten Sensitivity and Autoimmunity. A Case Report. European Journal of Case Reports in Internal Medicine, 1(1). https://doi.org/https://doi.org/10.12890/2014_000156