Panitumumab-Induced Eruptive Seborrhoeic Keratosis in a Patient with Metastatic Colorectal Cancer
  • Dimitra Koumaki
    Dermatology Department, University Hospital of Heraklion, PAGNI, Heraklion, Crete, Greece
  • Sotirios Boumpoucheropoulos
    Medical Oncology Department, Agii Anargiri General Oncological Hospital of Kifisia, Athens, Greec
  • Vasiliki Koumaki
    Department of Microbiology, Medical School of Athens, Greece
  • Alexander Katoulis
    Department of Dermatology, Attikon University Hospital, Athens, Greece
  • Georgia Pappas
    Medical Oncology Department, Agii Anargiri General Oncological Hospital of Kifisia, Athens, Greece
  • Aikaterini Mantaka
    Department of Gastroenterology, University Hospital of Heraklion, PAGNI, Heraklion, Crete, Greece
  • Konstantinos Krasagakis
    Dermatology Department, University Hospital of Heraklion, PAGNI, Heraklion, Crete, Greece

Keywords

Panitumumab, eruptive seborrhoeic keratosis, drug-induced eruption

Abstract

Objectives: Agents targeting the epidermal growth factor receptor (EGFR)-mediated signalling pathway are increasingly being used for the treatment of advanced lung, pancreatic, colorectal and head and neck cancers.
Case presentation: Here, we report the first case of eruptive seborrhoeic keratosis following panitumumab treatment, an anti-EGFR monoclonal antibody, in a 73-year-old patient with stage 4 (IV) colorectal cancer with hepatic metastasis.
Conclusion: While panitumumab is an emerging therapy for RAS wild-type metastatic colorectal cancer, physicians should consider panitumumab as a potential cause of eruptive seborrhoeic keratosis.

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    Published: 2020-01-15
    Issue: 2020: Vol 7 No 2 (view)


    How to cite:
    1.
    Koumaki D, Boumpoucheropoulos S, Koumaki V, Katoulis A, Pappas G, Mantaka A, Krasagakis K. Panitumumab-Induced Eruptive Seborrhoeic Keratosis in a Patient with Metastatic Colorectal Cancer. EJCRIM 2020;7 doi:10.12890/2020_001411.

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