Panitumumab-Induced Eruptive Seborrhoeic Keratosis in a Patient with Metastatic Colorectal Cancer

  • Dimitra Koumaki Dermatology Department, University Hospital of Heraklion, PAGNI, Heraklion, Crete, Greece
  • Sotirios Boumpoucheropoulos Medical Oncology Department, Agii Anargiri General Oncological Hospital of Kifisia, Athens, Greec
  • Vasiliki Koumaki Department of Microbiology, Medical School of Athens, Greece
  • Alexander Katoulis Department of Dermatology, Attikon University Hospital, Athens, Greece
  • Georgia Pappas Medical Oncology Department, Agii Anargiri General Oncological Hospital of Kifisia, Athens, Greece
  • Aikaterini Mantaka Department of Gastroenterology, University Hospital of Heraklion, PAGNI, Heraklion, Crete, Greece
  • Konstantinos Krasagakis Dermatology Department, University Hospital of Heraklion, PAGNI, Heraklion, Crete, Greece
DOI: https://doi.org/10.12890/2020_001411

Keywords

Panitumumab, eruptive seborrhoeic keratosis, drug-induced eruption

Abstract

Objectives: Agents targeting the epidermal growth factor receptor (EGFR)-mediated signalling pathway are increasingly being used for the treatment of advanced lung, pancreatic, colorectal and head and neck cancers.
Case presentation: Here, we report the first case of eruptive seborrhoeic keratosis following panitumumab treatment, an anti-EGFR monoclonal antibody, in a 73-year-old patient with stage 4 (IV) colorectal cancer with hepatic metastasis.
Conclusion: While panitumumab is an emerging therapy for RAS wild-type metastatic colorectal cancer, physicians should consider panitumumab as a potential cause of eruptive seborrhoeic keratosis.

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    • Published: 2020-01-15

    Issue: Vol 7 No 2 (view)

    Section: Articles

    How to cite:
    1.
    Koumaki D, Boumpoucheropoulos S, Koumaki V, Katoulis A, Pappas G, Mantaka A, Krasagakis K. Panitumumab-Induced Eruptive Seborrhoeic Keratosis in a Patient with Metastatic Colorectal Cancer. EJCRIM 2020;7 doi:10.12890/2020_001411.

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