Ozone Therapy for Oral Palatal Ulcer in a Leukaemic Patient

  • Giacomo Oldoini Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy
  • Giulia Ricci Frabattista Private practice, Liguria, Italy
  • Maria Saragoni Private practice, Liguria, Italy
  • Saverio Cosola Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy
  • Enrica Giammarinaro Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy
  • Anna Maria Genovesi Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy
  • Simone Marconcini Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy

Keywords

Ozone therapy, leukaemia, adjuvant therapy, oral ulcer, oral fungal infections, ozone, dentistry

Abstract

Chemotherapy usually causes complications affecting several tissues such as oral mucosa. In this case report, a soft palate oral ulcer caused by chemotherapy was treated by ozone gas. This kind of treatment is known for its antimicrobial, regenerative and analgesic proprieties. The results show a complete resolution of the lesion within 2 weeks of treatment. Ozone therapy demonstrates greater effectiveness with respect to this kind of oral lesion compared to traditional therapy. Considering this evidence, ozone therapy should be considered as a useful tool for the adjuvant therapy of oral complications in oncologic patients.

VIEW THE ENTIRE ARTICLE

References

  • Peterson DE, Srivastava R, Lalla RV. Oral mucosal injury in oncology patients: perspectives on maturation of a field. Oral Dis 2015;21(2):133–141.

  • Pai A, Prasad S, Dyasanoor S. Acute leukemias: a dentist's perspective. Minerva Stomatol 2012;61(5):233–238.

  • Huth KC, Jakob FM, Saugel B, Cappello C, Paschos E, Hollweck R, et al. Effect of ozone on oral cells compared with established antimicrobials. Eur J Oral Sci 2006;114(5):435–440.

  • Iebba V, Totino V, Gagliardi A, Santangelo F, Cacciotti F, Trancassini M, et al. Eubiosis and dysbiosis: the two sides of the microbiota. New Microbiol 2016;39(1):1–12.

  • Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res 2006;37(4):425–435.

  • Saini R. Ozone therapy in dentistry: a strategic review. J Nat Sci Biol Med 2011;2(2):151–153.

  • Roy D, Wong PK, Engelbrecht RS, Chian ES. Mechanism of enteroviral inactivation by ozone. Appl Environ Microbiol 1981;41(3):718–723.

  • Seydanur Dengizek E, Serkan D, Abubekir E, Aysun Bay K, Onder O, Arife C. Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial. J Appl Oral Sci 2019;27:e20180108.

  • Agrillo A, Ungari C, Filiaci F, Priore P, Iannetti G. Ozone therapy in the treatment of avascular bisphosphonate-related jaw osteonecrosis. J Craniofac Surg 2007;18(5):1071–1075.

  • Kazancioglu HO, Erisen M. Comparison of low-level laser therapy versus ozone therapy in the treatment of oral lichen planus. Ann Dermatol 2015;27(5):485–491.

  • Kaur A, Bhavikatti SK, Das SS, Khanna S, Jain M, Kaur A. Efficacy of ozonised water and 0.2% chlorhexidine gluconate in the management of chronic periodontitis when used as an irrigant in conjugation with phase I therapy. J Contemp Dent Pract 2019;20(3):318–323.

  • Dodwad V, Gupta S, Kumar K, Sethi M, Masamatti S. Changing paradigm in pocket therapy - ozone vs conventional irrigation. Int J of Public Health Dent 2011:2(2):7–12.

  • Cosola S, Giammarinaro E, Genovesi AM, Pisante R, Poli G, Covani U, et al. A short-term study of the effects of ozone irrigation in an orthodontic population with fixed appliances. Eur J Paediatr Dent 2019;20(1):15–18.

  • Kaimala S, Al-Sbiei A, Cabral-Marques O, Fernandez-Cabezudo MJ, Al-Ramadi BK. Attenuated bacteria as immunotherapeutic tools for cancer treatment. Front Oncol 2018;8:136.

  • Akdeniz SS, Beyler E, Korkmaz Y, Yurtcu E, Ates U, Araz K, et al. The effects of ozone application on genotoxic damage and wound healing in bisphosphonate-applied human gingival fibroblast cells. Clin Oral Investig 2018;22(2):867–873.

  • Nogales CG, Ferrari PH, Kantorovich EO, Lage-Marques JL. Ozone therapy in medicine and dentistry. J Contemp Dent Pract 2008;9(4):75–84.
  • Published: 2020-01-14

    Issue: LATEST ONLINE (view)

    Section: Articles

    How to cite:
    Oldoini, G., Ricci Frabattista, G., Saragoni, M., Cosola, S., Giammarinaro, E., Genovesi, A., & Marconcini, S. (2020). Ozone Therapy for Oral Palatal Ulcer in a Leukaemic Patient. European Journal of Case Reports in Internal Medicine, 2. https://doi.org/https://doi.org/10.12890/2020_001406

    Most read articles by the same author(s)